Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 897 | 79 | 806 |
| Samples | 316 | 27 | 285 |
| Peptides | 260 | 26 | 243 |
Function
EEF1AKNMT · EEF1A lysine and N-terminal methyltransferase
Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (EEF1A1 and EEF1A2) at two different positions, and is therefore involved in the regulation of mRNA translation (PubMed:30143613, PubMed:30612740). Via its C-terminus, methylates EEF1A1 and EEF1A2 at the N-terminal residue 'Gly-2' (PubMed:30143613). Via its N-terminus dimethylates EEF1A1 and EEF1A2 at residue 'Lys-55' (PubMed:30143613, PubMed:30612740). Has no activity towards core histones H2A, H2B, H3 and H4 (PubMed:30612740)
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 246 amino-acid changes on canonical ENST00000361735 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in EEF1AKNMT · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in EEF1AKNMT – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 4/133 3% |
| Endometrial Carcinoma | 2/42 5% | 15/612 2% |
| Mesothelioma | 0/62 0% | 4/165 2% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 14/810 2% |
| Hodgkins Lymphoma | 1/16 6% | 1/122 1% |
| Gastric Carcinoma | 0/74 0% | 25/1809 1% |
| Colorectal Carcinoma | 3/143 2% | 41/3239 1% |
| Melanoma | 0/210 0% | 27/1899 1% |
| Bladder Carcinoma | 1/58 2% | 10/956 1% |
| Germ Cell Tumour | 1/25 4% | 1/169 1% |
| Non-Small Cell Lung Carcinoma | 1/304 0% | 16/1390 1% |
| Other Solid Cancers | 0/94 0% | 16/1515 1% |
| Rhabdomyosarcoma | 0/33 0% | 2/171 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 15/1592 1% |
| Cervical Carcinoma | 0/35 0% | 4/422 1% |
| Neuroendocrine Tumour | 2/154 1% | 4/577 1% |
| Other Sarcomas | 1/69 1% | 5/699 1% |
| Non-Cancerous | 0/104 0% | 7/830 1% |
| Hepatocellular Carcinoma | 0/46 0% | 14/2210 1% |
| Head and Neck Carcinoma | 0/85 0% | 9/1574 1% |
| Small Cell Lung Carcinoma | 1/9 11% | 3/752 0% |
| Osteosarcoma | 0/45 0% | 1/166 1% |
| Ovarian Carcinoma | 0/109 0% | 5/998 0% |
| Burkitts Lymphoma | 0/32 0% | 1/196 1% |
| Glioma | 1/52 2% | 7/2127 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 8/2550 0% |
| Kidney Carcinoma | 0/85 0% | 5/1862 0% |
| Esophageal Carcinoma | 0/23 0% | 2/769 0% |
Mutation Distribution
Where EEF1AKNMT is mutated · all tissues, split by cell line vs tissue
How many mutations in EEF1AKNMT were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 897 mutations in EEF1AKNMT
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|