Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 4,538 | 359 | 4,123 |
| Samples | 1,327 | 187 | 1,119 |
| Peptides | 792 | 116 | 694 |
Function
EGFR · Epidermal growth factor receptor
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020].
Isoforms & Proteins
5 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 703 amino-acid changes on canonical ENST00000275493 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in EGFR · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in EGFR – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Gastrointestinal Stromal Tumour | 0/0 0% | 41/133 31% |
| T-Lymphoblastic Leukemia | 7/40 18% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 35/304 12% | 176/1390 13% |
| Glioma | 4/52 8% | 239/2127 11% |
| Glioblastoma | 10/98 10% | 0/0 0% |
| Melanoma | 19/210 9% | 105/1899 6% |
| Hodgkins Lymphoma | 5/16 31% | 3/122 2% |
| Endometrial Carcinoma | 10/42 24% | 22/612 4% |
| Small Cell Lung Carcinoma | 0/9 0% | 36/752 5% |
| Other Solid Cancers | 7/94 7% | 50/1515 3% |
| Colorectal Carcinoma | 21/143 15% | 97/3239 3% |
| Plasma Cell Myeloma | 6/44 14% | 6/305 2% |
| Gastric Carcinoma | 2/74 3% | 49/1809 3% |
| Cervical Carcinoma | 2/35 6% | 10/422 2% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 19/810 2% |
| Osteosarcoma | 2/45 4% | 3/166 2% |
| Neuroendocrine Tumour | 3/154 2% | 10/577 2% |
| Other Sarcomas | 0/69 0% | 13/699 2% |
| Bladder Carcinoma | 0/58 0% | 17/956 2% |
| Esophageal Carcinoma | 2/23 9% | 11/769 1% |
| Head and Neck Carcinoma | 3/85 4% | 22/1574 1% |
| Esophageal Squamous Cell Carcinoma | 7/51 14% | 31/2550 1% |
| Breast Carcinoma | 8/144 6% | 40/3264 1% |
| Biliary Tract Carcinoma | 2/54 4% | 12/950 1% |
| Hepatocellular Carcinoma | 0/46 0% | 31/2210 1% |
| Ewings Sarcoma | 3/63 5% | 1/262 0% |
| Ovarian Carcinoma | 2/109 2% | 11/998 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Germ Cell Tumour | 0/25 0% | 2/169 1% |
| Non-Cancerous | 1/104 1% | 8/830 1% |
Mutation Distribution
Where EGFR is mutated · all tissues, split by cell line vs tissue
How many mutations in EGFR were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 4,538 mutations in EGFR
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|