Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 488 | 62 | 412 |
| Samples | 134 | 26 | 103 |
| Peptides | 109 | 18 | 88 |
Function
EI24 · EI24 autophagy associated transmembrane protein
This gene encodes a putative tumor suppressor and has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The encoded protein may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. This gene is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 1, 3, 7, and 8. [provided by RefSeq, Feb 2014].
Isoforms & Proteins
6 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000278903 | O14681 | 116 | 88 |
| ENST00000620753 | O14681 | 96 | 78 |
| ENST00000534546 | O14681-3 | 95 | 77 |
| ENST00000527235 | E9PK61* | 91 | 64 |
| ENST00000615917 | A0A087WTG1* | 45 | 37 |
| ENST00000618552 | A0A087WTG1* | 45 | 37 |
Gene Properties
Recurrent Mutations
All 88 amino-acid changes on canonical ENST00000278903 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in EI24 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in EI24 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Endometrial Carcinoma | 3/42 7% | 10/612 2% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Melanoma | 1/210 0% | 13/1899 1% |
| Colorectal Carcinoma | 6/143 4% | 15/3239 0% |
| Bladder Carcinoma | 0/58 0% | 6/956 1% |
| Non-Cancerous | 0/104 0% | 5/830 1% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Burkitts Lymphoma | 0/32 0% | 1/196 1% |
| Mesothelioma | 0/62 0% | 1/165 1% |
| Biliary Tract Carcinoma | 0/54 0% | 4/950 0% |
| Hepatocellular Carcinoma | 1/46 2% | 8/2210 0% |
| Esophageal Carcinoma | 0/23 0% | 3/769 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 6/1592 0% |
| Gastric Carcinoma | 3/74 4% | 3/1809 0% |
| Ewings Sarcoma | 0/63 0% | 1/262 0% |
| Non-Small Cell Lung Carcinoma | 3/304 1% | 2/1390 0% |
| Plasma Cell Myeloma | 0/44 0% | 1/305 0% |
| Ovarian Carcinoma | 0/109 0% | 3/998 0% |
| Other Solid Cancers | 0/94 0% | 4/1515 0% |
| Glioma | 1/52 2% | 4/2127 0% |
| Cervical Carcinoma | 0/35 0% | 1/422 0% |
| B-Cell Non-Hodgkins Lymphoma | 2/88 2% | 3/2534 0% |
| Other Sarcomas | 0/69 0% | 1/699 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 1/810 0% |
| Pancreatic Carcinoma | 0/89 0% | 2/1611 0% |
| Prostate Carcinoma | 0/13 0% | 2/2105 0% |
| Breast Carcinoma | 2/144 1% | 1/3264 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 2/2550 0% |
Mutation Distribution
Where EI24 is mutated · all tissues, split by cell line vs tissue
How many mutations in EI24 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 488 mutations in EI24
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|