Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 774 | 109 | 659 |
| Samples | 209 | 45 | 161 |
| Peptides | 167 | 33 | 136 |
Function
EIF2A · Eukaryotic translation initiation factor 2A
This gene encodes a eukaryotic translation initiation factor that catalyzes the formation of puromycin-sensitive 80 S preinitiation complexes and the poly(U)-directed synthesis of polyphenylalanine at low concentrations of Mg2+. This gene should not be confused with eIF2-alpha (EIF2S1, Gene ID: 1965), the alpha subunit of the eIF2 translation initiation complex. Although both of these proteins function in binding initiator tRNA to the 40 S ribosomal subunit, the encoded protein does so in a codon-dependent manner, whereas eIF2 complex requires GTP. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016].
Isoforms & Proteins
4 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 153 amino-acid changes on canonical ENST00000460851 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in EIF2A · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in EIF2A – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Acute Myeloid Leukemia | 4/90 4% | 0/0 0% |
| Chronic Myelogenous Leukemia | 1/25 4% | 0/0 0% |
| Endometrial Carcinoma | 6/42 14% | 14/612 2% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 3/133 2% |
| Chondrosarcoma | 1/14 7% | 0/75 0% |
| Colorectal Carcinoma | 6/143 4% | 25/3239 1% |
| Non-Small Cell Lung Carcinoma | 7/304 2% | 8/1390 1% |
| Cervical Carcinoma | 2/35 6% | 2/422 0% |
| Melanoma | 1/210 0% | 16/1899 1% |
| Ovarian Carcinoma | 5/109 5% | 3/998 0% |
| Bladder Carcinoma | 1/58 2% | 5/956 1% |
| Hepatocellular Carcinoma | 0/46 0% | 13/2210 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 4/752 1% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Rhabdomyosarcoma | 0/33 0% | 1/171 1% |
| Head and Neck Carcinoma | 1/85 1% | 7/1574 0% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
| Burkitts Lymphoma | 0/32 0% | 1/196 1% |
| Gastric Carcinoma | 0/74 0% | 8/1809 0% |
| Thyroid Gland Carcinoma | 2/45 4% | 4/1592 0% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 2/810 0% |
| Kidney Carcinoma | 5/85 6% | 1/1862 0% |
| Ewings Sarcoma | 0/63 0% | 1/262 0% |
| B-Cell Non-Hodgkins Lymphoma | 0/88 0% | 8/2534 0% |
| Breast Carcinoma | 0/144 0% | 10/3264 0% |
| Plasma Cell Myeloma | 1/44 2% | 0/305 0% |
| Other Solid Cancers | 0/94 0% | 4/1515 0% |
| Other Blood Cancers | 0/61 0% | 6/2725 0% |
| Non-Cancerous | 0/104 0% | 2/830 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 5/2550 0% |
Mutation Distribution
Where EIF2A is mutated · all tissues, split by cell line vs tissue
How many mutations in EIF2A were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 774 mutations in EIF2A
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|