Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 911 | 153 | 733 |
| Samples | 447 | 91 | 342 |
| Peptides | 387 | 68 | 319 |
Function
EIF5B · Eukaryotic translation initiation factor 5B
Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000289371 | O60841 | 481 | 373 |
| ENST00000617677 | - | 430 | 352 |
Gene Properties
Recurrent Mutations
All 373 amino-acid changes on canonical ENST00000289371 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in EIF5B · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in EIF5B – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 5/40 12% | 0/0 0% |
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| Endometrial Carcinoma | 9/42 21% | 23/612 4% |
| Glioblastoma | 3/98 3% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 3/133 2% |
| Non-Small Cell Lung Carcinoma | 11/304 4% | 18/1390 1% |
| Colorectal Carcinoma | 12/143 8% | 45/3239 1% |
| Melanoma | 5/210 2% | 27/1899 1% |
| Bladder Carcinoma | 1/58 2% | 14/956 1% |
| Hodgkins Lymphoma | 1/16 6% | 1/122 1% |
| Plasma Cell Myeloma | 5/44 11% | 0/305 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 23/1592 1% |
| Gastric Carcinoma | 1/74 1% | 24/1809 1% |
| Cervical Carcinoma | 1/35 3% | 5/422 1% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 9/810 1% |
| Other Solid Cancers | 2/94 2% | 17/1515 1% |
| Esophageal Carcinoma | 0/23 0% | 9/769 1% |
| Ovarian Carcinoma | 3/109 3% | 9/998 1% |
| Germ Cell Tumour | 0/25 0% | 2/169 1% |
| Head and Neck Carcinoma | 5/85 6% | 11/1574 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 7/752 1% |
| Esophageal Squamous Cell Carcinoma | 2/51 4% | 19/2550 1% |
| Hepatocellular Carcinoma | 1/46 2% | 17/2210 1% |
| Glioma | 2/52 4% | 15/2127 1% |
| Biliary Tract Carcinoma | 2/54 4% | 5/950 1% |
| Osteosarcoma | 0/45 0% | 1/166 1% |
| Kidney Carcinoma | 1/85 1% | 8/1862 0% |
| Burkitts Lymphoma | 0/32 0% | 1/196 1% |
| Non-Cancerous | 0/104 0% | 4/830 0% |
| Neuroendocrine Tumour | 1/154 1% | 2/577 0% |
Mutation Distribution
Where EIF5B is mutated · all tissues, split by cell line vs tissue
How many mutations in EIF5B were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 911 mutations in EIF5B
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|