Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 2,781 | 369 | 2,379 |
| Samples | 1,079 | 195 | 869 |
| Peptides | 849 | 125 | 747 |
Function
EPHA3 · EPH receptor A3
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 822 amino-acid changes on canonical ENST00000336596 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in EPHA3 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in EPHA3 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 3/25 12% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 3/26 12% | 0/0 0% |
| T-Lymphoblastic Leukemia | 4/40 10% | 0/0 0% |
| Glioblastoma | 8/98 8% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 34/304 11% | 89/1390 6% |
| Melanoma | 11/210 5% | 124/1899 7% |
| Endometrial Carcinoma | 2/42 5% | 39/612 6% |
| Acute Myeloid Leukemia | 5/90 6% | 0/0 0% |
| Squamous Cell Lung Carcinoma | 5/57 9% | 42/810 5% |
| Other Solid Cancers | 8/94 9% | 72/1515 5% |
| Colorectal Carcinoma | 20/143 14% | 108/3239 3% |
| Gastric Carcinoma | 5/74 7% | 64/1809 4% |
| Esophageal Carcinoma | 1/23 4% | 26/769 3% |
| Hodgkins Lymphoma | 1/16 6% | 3/122 2% |
| Neuroendocrine Tumour | 13/154 8% | 7/577 1% |
| Thymic Epithelial Tumor | 0/0 0% | 1/39 3% |
| Bladder Carcinoma | 1/58 2% | 24/956 3% |
| Small Cell Lung Carcinoma | 1/9 11% | 17/752 2% |
| Plasma Cell Myeloma | 3/44 7% | 5/305 2% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 3/133 2% |
| Cervical Carcinoma | 2/35 6% | 7/422 2% |
| Hepatocellular Carcinoma | 3/46 7% | 40/2210 2% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Head and Neck Carcinoma | 4/85 5% | 25/1574 2% |
| Germ Cell Tumour | 2/25 8% | 1/169 1% |
| Ovarian Carcinoma | 6/109 6% | 11/998 1% |
| Burkitts Lymphoma | 3/32 9% | 0/196 0% |
| Glioma | 2/52 4% | 26/2127 1% |
| Chondrosarcoma | 0/14 0% | 1/75 1% |
| Biliary Tract Carcinoma | 0/54 0% | 11/950 1% |
Mutation Distribution
Where EPHA3 is mutated · all tissues, split by cell line vs tissue
How many mutations in EPHA3 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 2,781 mutations in EPHA3
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|