Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,121 | 187 | 912 |
| Samples | 727 | 136 | 577 |
| Peptides | 544 | 96 | 459 |
Function
EPHA8 · EPH receptor A8
This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 505 amino-acid changes on canonical ENST00000166244 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in EPHA8 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in EPHA8 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Acute Myeloid Leukemia | 6/90 7% | 0/0 0% |
| Oral Cavity Carcinoma | 3/54 6% | 0/0 0% |
| Endometrial Carcinoma | 7/42 17% | 27/612 4% |
| Melanoma | 15/210 7% | 85/1899 4% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 21/304 7% | 41/1390 3% |
| Colorectal Carcinoma | 15/143 10% | 87/3239 3% |
| Gastric Carcinoma | 3/74 4% | 46/1809 3% |
| Unknown | 1/10 10% | 0/29 0% |
| Thymic Epithelial Tumor | 0/0 0% | 1/39 3% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 17/810 2% |
| Bladder Carcinoma | 0/58 0% | 23/956 2% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 3/133 2% |
| Neuroendocrine Tumour | 10/154 6% | 6/577 1% |
| Other Solid Cancers | 1/94 1% | 34/1515 2% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Burkitts Lymphoma | 4/32 12% | 0/196 0% |
| Esophageal Carcinoma | 1/23 4% | 12/769 2% |
| Cervical Carcinoma | 0/35 0% | 7/422 2% |
| Hodgkins Lymphoma | 0/16 0% | 2/122 2% |
| Plasma Cell Myeloma | 2/44 5% | 3/305 1% |
| Glioma | 0/52 0% | 31/2127 1% |
| Other Sarcomas | 0/69 0% | 10/699 1% |
| Head and Neck Carcinoma | 3/85 4% | 17/1574 1% |
| Ovarian Carcinoma | 4/109 4% | 9/998 1% |
| Biliary Tract Carcinoma | 1/54 2% | 8/950 1% |
| Non-Cancerous | 0/104 0% | 8/830 1% |
| Hepatocellular Carcinoma | 2/46 4% | 17/2210 1% |
| Esophageal Squamous Cell Carcinoma | 4/51 8% | 17/2550 1% |
Mutation Distribution
Where EPHA8 is mutated · all tissues, split by cell line vs tissue
How many mutations in EPHA8 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 52 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,121 mutations in EPHA8
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|