Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 2,736 | 362 | 2,344 |
| Samples | 633 | 121 | 503 |
| Peptides | 507 | 103 | 426 |
Function
EPHB2 · EPH receptor B2
This gene encodes a member of the Eph receptor family of receptor tyrosine kinase transmembrane glycoproteins. These receptors are composed of an N-terminal glycosylated ligand-binding domain, a transmembrane region and an intracellular kinase domain. They bind ligands called ephrins and are involved in diverse cellular processes including motility, division, and differentiation. A distinguishing characteristic of Eph-ephrin signaling is that both receptors and ligands are competent to transduce a signaling cascade, resulting in bidirectional signaling. This protein belongs to a subgroup of the Eph receptors called EphB. Proteins of this subgroup are distinguished from other members of the family by sequence homology and preferential binding affinity for membrane-bound ephrin-B ligands. Allelic variants are associated with prostate and brain cancer susceptibility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015].
Isoforms & Proteins
5 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 442 amino-acid changes on canonical ENST00000374630 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in EPHB2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in EPHB2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Melanoma | 13/210 6% | 111/1899 6% |
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Endometrial Carcinoma | 8/42 19% | 23/612 4% |
| Acute Myeloid Leukemia | 4/90 4% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 15/304 5% | 30/1390 2% |
| Gastric Carcinoma | 8/74 11% | 39/1809 2% |
| Other Solid Cancers | 2/94 2% | 35/1515 2% |
| Hodgkins Lymphoma | 0/16 0% | 3/122 2% |
| Colorectal Carcinoma | 17/143 12% | 52/3239 2% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Neuroendocrine Tumour | 8/154 5% | 5/577 1% |
| Plasma Cell Myeloma | 5/44 11% | 1/305 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 13/752 2% |
| Other Sarcomas | 5/69 7% | 6/699 1% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 11/810 1% |
| Cervical Carcinoma | 0/35 0% | 6/422 1% |
| Ovarian Carcinoma | 6/109 6% | 6/998 1% |
| Bladder Carcinoma | 1/58 2% | 10/956 1% |
| Hepatocellular Carcinoma | 0/46 0% | 22/2210 1% |
| Non-Cancerous | 0/104 0% | 9/830 1% |
| Osteosarcoma | 1/45 2% | 1/166 1% |
| Burkitts Lymphoma | 0/32 0% | 2/196 1% |
| Meningioma | 0/3 0% | 2/252 1% |
| Glioma | 0/52 0% | 17/2127 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 12/1592 1% |
| Esophageal Squamous Cell Carcinoma | 4/51 8% | 13/2550 1% |
| Head and Neck Carcinoma | 1/85 1% | 9/1574 1% |
| B-Cell Non-Hodgkins Lymphoma | 6/88 7% | 9/2534 0% |
| Breast Carcinoma | 0/144 0% | 19/3264 1% |
| Kidney Carcinoma | 3/85 4% | 8/1862 0% |
Mutation Distribution
Where EPHB2 is mutated · all tissues, split by cell line vs tissue
How many mutations in EPHB2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 2,736 mutations in EPHB2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|