Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 404 | 30 | 355 |
| Samples | 156 | 27 | 126 |
| Peptides | 116 | 25 | 87 |
Function
FBXL8 · F-box and leucine rich repeat protein 8
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. It shares 78% sequence identity with the mouse protein. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
4 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 107 amino-acid changes on canonical ENST00000258200 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in FBXL8 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in FBXL8 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 1/40 2% | 0/0 0% |
| Other Solid Cancers | 0/94 0% | 38/1515 3% |
| Endometrial Carcinoma | 1/42 2% | 8/612 1% |
| Gastric Carcinoma | 1/74 1% | 18/1809 1% |
| Burkitts Lymphoma | 2/32 6% | 0/196 0% |
| Melanoma | 1/210 0% | 13/1899 1% |
| Thyroid Gland Carcinoma | 2/45 4% | 8/1592 0% |
| Colorectal Carcinoma | 3/143 2% | 16/3239 0% |
| Non-Cancerous | 1/104 1% | 4/830 0% |
| Plasma Cell Myeloma | 1/44 2% | 0/305 0% |
| Head and Neck Carcinoma | 2/85 2% | 2/1574 0% |
| Non-Small Cell Lung Carcinoma | 1/304 0% | 3/1390 0% |
| Cervical Carcinoma | 0/35 0% | 1/422 0% |
| Bladder Carcinoma | 1/58 2% | 1/956 0% |
| Breast Carcinoma | 3/144 2% | 3/3264 0% |
| Neuroendocrine Tumour | 1/154 1% | 0/577 0% |
| Esophageal Carcinoma | 0/23 0% | 1/769 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 1/810 0% |
| Pancreatic Carcinoma | 1/89 1% | 1/1611 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 3/2550 0% |
| B-Cell Non-Hodgkins Lymphoma | 1/88 1% | 2/2534 0% |
| B-Lymphoblastic Leukemia | 2/55 4% | 1/2640 0% |
| Kidney Carcinoma | 1/85 1% | 1/1862 0% |
| Biliary Tract Carcinoma | 0/54 0% | 1/950 0% |
| Ovarian Carcinoma | 1/109 1% | 0/998 0% |
| Hepatocellular Carcinoma | 0/46 0% | 2/2210 0% |
| Prostate Carcinoma | 0/13 0% | 1/2105 0% |
Mutation Distribution
Where FBXL8 is mutated · all tissues, split by cell line vs tissue
How many mutations in FBXL8 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 404 mutations in FBXL8
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|