Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 175 | 38 | 132 |
| Samples | 171 | 38 | 128 |
| Peptides | 135 | 25 | 115 |
Function
FBXW2 · F-box and WD repeat domain containing 2
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000608872 | Q9UKT8 | 175 | 135 |
Gene Properties
Recurrent Mutations
All 135 amino-acid changes on canonical ENST00000608872 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in FBXW2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in FBXW2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 4/40 10% | 0/0 0% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Germ Cell Tumour | 1/25 4% | 1/169 1% |
| Melanoma | 4/210 2% | 17/1899 1% |
| Mesothelioma | 2/62 3% | 0/165 0% |
| Endometrial Carcinoma | 2/42 5% | 3/612 0% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Bladder Carcinoma | 3/58 5% | 4/956 0% |
| Gastric Carcinoma | 0/74 0% | 13/1809 1% |
| Neuroendocrine Tumour | 2/154 1% | 3/577 1% |
| Other Sarcomas | 3/69 4% | 2/699 0% |
| Colorectal Carcinoma | 0/143 0% | 21/3239 1% |
| Small Cell Lung Carcinoma | 2/9 22% | 2/752 0% |
| Biliary Tract Carcinoma | 0/54 0% | 5/950 1% |
| Burkitts Lymphoma | 1/32 3% | 0/196 0% |
| Thyroid Gland Carcinoma | 2/45 4% | 5/1592 0% |
| Head and Neck Carcinoma | 0/85 0% | 6/1574 0% |
| Other Solid Cancers | 0/94 0% | 5/1515 0% |
| Ewings Sarcoma | 1/63 2% | 0/262 0% |
| Non-Small Cell Lung Carcinoma | 0/304 0% | 5/1390 0% |
| Ovarian Carcinoma | 1/109 1% | 2/998 0% |
| Hepatocellular Carcinoma | 0/46 0% | 6/2210 0% |
| Esophageal Carcinoma | 0/23 0% | 2/769 0% |
| Cervical Carcinoma | 0/35 0% | 1/422 0% |
| Medulloblastoma | 0/0 0% | 1/450 0% |
| Kidney Carcinoma | 0/85 0% | 4/1862 0% |
| Breast Carcinoma | 0/144 0% | 7/3264 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 5/2550 0% |
| B-Cell Non-Hodgkins Lymphoma | 2/88 2% | 3/2534 0% |
Mutation Distribution
Where FBXW2 is mutated · all tissues, split by cell line vs tissue
How many mutations in FBXW2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 175 mutations in FBXW2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|