Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 567 | 82 | 484 |
| Samples | 286 | 54 | 231 |
| Peptides | 211 | 40 | 174 |
Function
FBXW8 · F-box and WD repeat domain containing 8
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000652555 | Q8N3Y1 | 304 | 200 |
| ENST00000455858 | Q8N3Y1-2 | 259 | 180 |
| ENST00000309909 | A0A499FIY5* | 4 | 4 |
Gene Properties
Recurrent Mutations
All 200 amino-acid changes on canonical ENST00000652555 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in FBXW8 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in FBXW8 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Gastrointestinal Stromal Tumour | 0/0 0% | 6/133 5% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Burkitts Lymphoma | 6/32 19% | 2/196 1% |
| Endometrial Carcinoma | 4/42 10% | 16/612 3% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Melanoma | 6/210 3% | 30/1899 2% |
| Colorectal Carcinoma | 8/143 6% | 38/3239 1% |
| Bladder Carcinoma | 1/58 2% | 12/956 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Other Solid Cancers | 1/94 1% | 15/1515 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 15/1592 1% |
| Cervical Carcinoma | 0/35 0% | 4/422 1% |
| Non-Small Cell Lung Carcinoma | 4/304 1% | 9/1390 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Gastric Carcinoma | 4/74 5% | 9/1809 0% |
| Non-Cancerous | 1/104 1% | 5/830 1% |
| Hepatocellular Carcinoma | 2/46 4% | 12/2210 1% |
| Biliary Tract Carcinoma | 0/54 0% | 6/950 1% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 5/810 1% |
| Neuroendocrine Tumour | 3/154 2% | 0/577 0% |
| Glioma | 1/52 2% | 6/2127 0% |
| Breast Carcinoma | 3/144 2% | 8/3264 0% |
| Ewings Sarcoma | 0/63 0% | 1/262 0% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 7/2550 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 2/752 0% |
| Kidney Carcinoma | 1/85 1% | 4/1862 0% |
| Esophageal Carcinoma | 0/23 0% | 2/769 0% |
| Head and Neck Carcinoma | 0/85 0% | 4/1574 0% |
| Medulloblastoma | 0/0 0% | 1/450 0% |
Mutation Distribution
Where FBXW8 is mutated · all tissues, split by cell line vs tissue
How many mutations in FBXW8 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 567 mutations in FBXW8
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|