Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 816 | 127 | 681 |
| Samples | 283 | 65 | 213 |
| Peptides | 220 | 43 | 178 |
Function
FGR · FGR proto-oncogene, Src family tyrosine kinase
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 220 amino-acid changes on canonical ENST00000374005 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in FGR · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in FGR – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 7/40 18% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 3/26 12% | 0/0 0% |
| Melanoma | 2/210 1% | 53/1899 3% |
| Endometrial Carcinoma | 4/42 10% | 13/612 2% |
| Unknown | 1/10 10% | 0/29 0% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Bladder Carcinoma | 4/58 7% | 9/956 1% |
| Colorectal Carcinoma | 6/143 4% | 28/3239 1% |
| Non-Small Cell Lung Carcinoma | 12/304 4% | 5/1390 0% |
| Cervical Carcinoma | 0/35 0% | 4/422 1% |
| Burkitts Lymphoma | 2/32 6% | 0/196 0% |
| Other Solid Cancers | 2/94 2% | 11/1515 1% |
| Gastric Carcinoma | 0/74 0% | 13/1809 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 5/752 1% |
| Plasma Cell Myeloma | 2/44 5% | 0/305 0% |
| Ovarian Carcinoma | 1/109 1% | 5/998 0% |
| Germ Cell Tumour | 1/25 4% | 0/169 0% |
| Other Sarcomas | 4/69 6% | 0/699 0% |
| Prostate Carcinoma | 0/13 0% | 10/2105 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 7/1592 0% |
| Neuroendocrine Tumour | 2/154 1% | 1/577 0% |
| Kidney Carcinoma | 2/85 2% | 6/1862 0% |
| Esophageal Carcinoma | 0/23 0% | 3/769 0% |
| Hepatocellular Carcinoma | 0/46 0% | 8/2210 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 3/810 0% |
| B-Cell Non-Hodgkins Lymphoma | 4/88 5% | 5/2534 0% |
| Glioma | 0/52 0% | 5/2127 0% |
| Breast Carcinoma | 0/144 0% | 7/3264 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 5/2550 0% |
| Other Blood Cancers | 0/61 0% | 5/2725 0% |
Mutation Distribution
Where FGR is mutated · all tissues, split by cell line vs tissue
How many mutations in FGR were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 816 mutations in FGR
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|