Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 948 | 132 | 810 |
| Samples | 881 | 124 | 751 |
| Peptides | 532 | 77 | 466 |
Function
FLT3 · Fms related receptor tyrosine kinase 3
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000241453 | P36888 | 948 | 532 |
Gene Properties
Recurrent Mutations
All 533 amino-acid changes on canonical ENST00000241453 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in FLT3 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in FLT3 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 8/40 20% | 0/0 0% |
| Acute Myeloid Leukemia | 8/90 9% | 0/0 0% |
| Endometrial Carcinoma | 11/42 26% | 26/612 4% |
| Melanoma | 9/210 4% | 104/1899 5% |
| Other Blood Cancers | 1/61 2% | 142/2725 5% |
| Acute Monocytic Leukemia | 0/1 0% | 1/25 4% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 5/133 4% |
| B-Lymphoblastic Leukemia | 2/55 4% | 96/2640 4% |
| Non-Small Cell Lung Carcinoma | 20/304 7% | 34/1390 2% |
| Other Solid Cancers | 2/94 2% | 49/1515 3% |
| Pheochromocytoma and Paraganglioma | 0/0 0% | 2/71 3% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 18/810 2% |
| Esophageal Carcinoma | 2/23 9% | 13/769 2% |
| Neuroendocrine Tumour | 9/154 6% | 4/577 1% |
| Colorectal Carcinoma | 13/143 9% | 47/3239 1% |
| Bladder Carcinoma | 1/58 2% | 16/956 2% |
| Ovarian Carcinoma | 5/109 5% | 12/998 1% |
| Osteosarcoma | 3/45 7% | 0/166 0% |
| Hepatocellular Carcinoma | 5/46 11% | 26/2210 1% |
| Small Cell Lung Carcinoma | 1/9 11% | 9/752 1% |
| Cervical Carcinoma | 0/35 0% | 6/422 1% |
| Glioma | 0/52 0% | 26/2127 1% |
| Gastric Carcinoma | 0/74 0% | 22/1809 1% |
| Germ Cell Tumour | 0/25 0% | 2/169 1% |
| Rhabdomyosarcoma | 0/33 0% | 2/171 1% |
| Burkitts Lymphoma | 2/32 6% | 0/196 0% |
| Breast Carcinoma | 3/144 2% | 24/3264 1% |
| Head and Neck Carcinoma | 1/85 1% | 11/1574 1% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 14/2550 1% |
| Plasma Cell Myeloma | 0/44 0% | 2/305 1% |
Mutation Distribution
Where FLT3 is mutated · all tissues, split by cell line vs tissue
How many mutations in FLT3 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 53 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 948 mutations in FLT3
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|