Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,260 | 139 | 1,095 |
| Samples | 604 | 69 | 521 |
| Peptides | 528 | 67 | 467 |
Function
FPGT-TNNI3K · FPGT-TNNI3K readthrough
This locus represents naturally occurring read-through transcription from the neighboring fucose-1-phosphate guanylyltransferase (FPGT) and TNNI3 interacting kinase (TNNI3K) genes. Alternative splicing results in multiple transcript variants that are composed of in-frame exons from each individual gene. [provided by RefSeq, Dec 2010]
Isoforms & Proteins
5 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000370899 | Q59H18-4 | 657 | 474 |
| ENST00000370895 | Q59H18-3 | 488 | 368 |
| ENST00000370893 | A6NHC7* | 68 | 58 |
| ENST00000557284 | Q59H18-1 | 46 | 41 |
| ENST00000648585 | A0A3B3ITB1* | 1 | 1 |
Gene Properties
Recurrent Mutations
All 474 amino-acid changes on canonical ENST00000370899 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in FPGT-TNNI3K · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in FPGT-TNNI3K – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Endometrial Carcinoma | 2/42 5% | 27/612 4% |
| Melanoma | 3/210 1% | 75/1899 4% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 30/810 4% |
| Non-Small Cell Lung Carcinoma | 20/304 7% | 36/1390 3% |
| Other Solid Cancers | 2/94 2% | 51/1515 3% |
| T-Lymphoblastic Leukemia | 1/40 2% | 0/0 0% |
| Gastric Carcinoma | 0/74 0% | 44/1809 2% |
| Colorectal Carcinoma | 7/143 5% | 59/3239 2% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Bladder Carcinoma | 0/58 0% | 16/956 2% |
| Small Cell Lung Carcinoma | 0/9 0% | 11/752 1% |
| Pheochromocytoma and Paraganglioma | 0/0 0% | 1/71 1% |
| Hepatocellular Carcinoma | 2/46 4% | 26/2210 1% |
| Esophageal Carcinoma | 0/23 0% | 9/769 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Esophageal Squamous Cell Carcinoma | 4/51 8% | 24/2550 1% |
| Ovarian Carcinoma | 3/109 3% | 9/998 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Biliary Tract Carcinoma | 0/54 0% | 10/950 1% |
| Prostate Carcinoma | 0/13 0% | 16/2105 1% |
| Non-Cancerous | 2/104 2% | 5/830 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Breast Carcinoma | 4/144 3% | 20/3264 1% |
| Other Sarcomas | 2/69 3% | 3/699 0% |
| Head and Neck Carcinoma | 1/85 1% | 9/1574 1% |
| Plasma Cell Myeloma | 0/44 0% | 2/305 1% |
| Neuroendocrine Tumour | 3/154 2% | 1/577 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 9/1592 1% |
| Pancreatic Carcinoma | 1/89 1% | 8/1611 0% |
| B-Cell Non-Hodgkins Lymphoma | 3/88 3% | 10/2534 0% |
Mutation Distribution
Where FPGT-TNNI3K is mutated · all tissues, split by cell line vs tissue
How many mutations in FPGT-TNNI3K were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 1,260 mutations in FPGT-TNNI3K
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|