Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 376 | 92 | 275 |
| Samples | 351 | 80 | 264 |
| Peptides | 268 | 59 | 208 |
Function
FZD8 · Frizzled class receptor 8
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000374694 | Q9H461 | 376 | 268 |
Gene Properties
Recurrent Mutations
All 268 amino-acid changes on canonical ENST00000374694 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in FZD8 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in FZD8 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 6/40 15% | 0/0 0% |
| Chronic Myelogenous Leukemia | 3/25 12% | 0/0 0% |
| Germ Cell Tumour | 5/25 20% | 1/169 1% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Colorectal Carcinoma | 12/143 8% | 57/3239 2% |
| Endometrial Carcinoma | 3/42 7% | 10/612 2% |
| Meningioma | 0/3 0% | 5/252 2% |
| Gastric Carcinoma | 1/74 1% | 31/1809 2% |
| Neuroendocrine Tumour | 6/154 4% | 5/577 1% |
| Hodgkins Lymphoma | 2/16 12% | 0/122 0% |
| Melanoma | 5/210 2% | 21/1899 1% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 28/2550 1% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 6/810 1% |
| Ovarian Carcinoma | 5/109 5% | 5/998 0% |
| Medulloblastoma | 0/0 0% | 4/450 1% |
| Cervical Carcinoma | 0/35 0% | 4/422 1% |
| Other Solid Cancers | 1/94 1% | 13/1515 1% |
| Adrenocortical Carcinoma | 0/3 0% | 1/112 1% |
| Biliary Tract Carcinoma | 1/54 2% | 7/950 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Glioma | 1/52 2% | 12/2127 1% |
| Non-Small Cell Lung Carcinoma | 2/304 1% | 8/1390 1% |
| Non-Cancerous | 0/104 0% | 5/830 1% |
| Rhabdomyosarcoma | 1/33 3% | 0/171 0% |
| Hepatocellular Carcinoma | 0/46 0% | 10/2210 0% |
| Thyroid Gland Carcinoma | 1/45 2% | 5/1592 0% |
| Kidney Carcinoma | 3/85 4% | 4/1862 0% |
| B-Cell Non-Hodgkins Lymphoma | 6/88 7% | 3/2534 0% |
| Bladder Carcinoma | 0/58 0% | 3/956 0% |
| Plasma Cell Myeloma | 1/44 2% | 0/305 0% |
Mutation Distribution
Where FZD8 is mutated · all tissues, split by cell line vs tissue
How many mutations in FZD8 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 376 mutations in FZD8
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|