Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 271 | 63 | 205 |
| Samples | 264 | 63 | 198 |
| Peptides | 184 | 34 | 152 |
Function
GABRR2 · Gamma-aminobutyric acid type A receptor subunit rho2
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. The protein encoded by this gene is a member of the rho subunit family and is a component of the GABA type A receptor complex. This gene exists on chromosome 6q next to the gene encoding the rho 1 subunit of the GABA type A receptor, in a region thought to be associated with susceptibility for psychiatric disorders and epilepsy. Polymorphisms in this gene may also be associated with alcohol dependence, and general cognitive ability. [provided by RefSeq, Apr 2016].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000402938 | P28476 | 271 | 184 |
Gene Properties
Recurrent Mutations
All 184 amino-acid changes on canonical ENST00000402938 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in GABRR2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in GABRR2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 1/25 4% | 0/0 0% |
| Endometrial Carcinoma | 3/42 7% | 14/612 2% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 2/133 2% |
| Hodgkins Lymphoma | 2/16 12% | 0/122 0% |
| Colorectal Carcinoma | 6/143 4% | 41/3239 1% |
| Squamous Cell Lung Carcinoma | 4/57 7% | 7/810 1% |
| Germ Cell Tumour | 2/25 8% | 0/169 0% |
| Non-Small Cell Lung Carcinoma | 1/304 0% | 16/1390 1% |
| Gastric Carcinoma | 1/74 1% | 17/1809 1% |
| Melanoma | 8/210 4% | 10/1899 1% |
| Other Solid Cancers | 2/94 2% | 10/1515 1% |
| Head and Neck Carcinoma | 2/85 2% | 10/1574 1% |
| Biliary Tract Carcinoma | 3/54 6% | 4/950 0% |
| Bladder Carcinoma | 2/58 3% | 5/956 1% |
| Neuroendocrine Tumour | 4/154 3% | 1/577 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 5/752 1% |
| Pancreatic Carcinoma | 4/89 4% | 6/1611 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 8/1592 0% |
| Breast Carcinoma | 3/144 2% | 11/3264 0% |
| Glioma | 0/52 0% | 8/2127 0% |
| Ovarian Carcinoma | 1/109 1% | 3/998 0% |
| Ewings Sarcoma | 1/63 2% | 0/262 0% |
| Hepatocellular Carcinoma | 0/46 0% | 6/2210 0% |
| Other Sarcomas | 0/69 0% | 2/699 0% |
| Esophageal Carcinoma | 0/23 0% | 2/769 0% |
| Cervical Carcinoma | 1/35 3% | 0/422 0% |
| Non-Cancerous | 0/104 0% | 2/830 0% |
| Esophageal Squamous Cell Carcinoma | 2/51 4% | 3/2550 0% |
| Prostate Carcinoma | 0/13 0% | 4/2105 0% |
Mutation Distribution
Where GABRR2 is mutated · all tissues, split by cell line vs tissue
How many mutations in GABRR2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 271 mutations in GABRR2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|