Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 409 | 35 | 373 |
| Samples | 377 | 35 | 341 |
| Peptides | 279 | 28 | 261 |
Function
GIMAP1-GIMAP5 · GIMAP1-GIMAP5 readthrough
This locus represents naturally occurring readthrough transcription between the neighboring GIMAP1 (GTPase, IMAP family member 1) and GIMAP5 (GTPase, IMAP family member 5) genes on chromosome 7. Alternative splicing results in multiple readthrough transcript variants, one of which encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Jan 2015].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000611999 | A0A087WTJ2* | 409 | 279 |
Gene Properties
Recurrent Mutations
All 279 amino-acid changes on canonical ENST00000611999 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in GIMAP1-GIMAP5 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in GIMAP1-GIMAP5 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Melanoma | 0/210 0% | 89/1899 5% |
| T-Lymphoblastic Leukemia | 1/40 2% | 0/0 0% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 19/810 2% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 7/304 2% | 24/1390 2% |
| Endometrial Carcinoma | 1/42 2% | 11/612 2% |
| Other Solid Cancers | 0/94 0% | 26/1515 2% |
| Small Cell Lung Carcinoma | 0/9 0% | 10/752 1% |
| Bladder Carcinoma | 0/58 0% | 12/956 1% |
| Colorectal Carcinoma | 2/143 1% | 33/3239 1% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Neuroendocrine Tumour | 2/154 1% | 5/577 1% |
| Ewings Sarcoma | 1/63 2% | 2/262 1% |
| Mesothelioma | 1/62 2% | 1/165 1% |
| Cervical Carcinoma | 1/35 3% | 3/422 1% |
| Esophageal Carcinoma | 0/23 0% | 6/769 1% |
| Hodgkins Lymphoma | 1/16 6% | 0/122 0% |
| Gastric Carcinoma | 2/74 3% | 10/1809 1% |
| Glioma | 0/52 0% | 13/2127 1% |
| Head and Neck Carcinoma | 0/85 0% | 10/1574 1% |
| Plasma Cell Myeloma | 1/44 2% | 1/305 0% |
| Ovarian Carcinoma | 0/109 0% | 6/998 1% |
| Germ Cell Tumour | 1/25 4% | 0/169 0% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
| Burkitts Lymphoma | 0/32 0% | 1/196 1% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 10/2550 0% |
| Breast Carcinoma | 0/144 0% | 14/3264 0% |
| Biliary Tract Carcinoma | 0/54 0% | 4/950 0% |
| Meningioma | 0/3 0% | 1/252 0% |
| Prostate Carcinoma | 1/13 8% | 7/2105 0% |
Mutation Distribution
Where GIMAP1-GIMAP5 is mutated · all tissues, split by cell line vs tissue
How many mutations in GIMAP1-GIMAP5 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 409 mutations in GIMAP1-GIMAP5
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|