Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 783 | 87 | 682 |
| Samples | 275 | 47 | 223 |
| Peptides | 249 | 29 | 220 |
Function
GPC3 · Glypican 3
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 222 amino-acid changes on canonical ENST00000370818 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in GPC3 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in GPC3 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Endometrial Carcinoma | 4/42 10% | 24/612 4% |
| Melanoma | 6/210 3% | 30/1899 2% |
| Non-Small Cell Lung Carcinoma | 15/304 5% | 13/1390 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 2/133 2% |
| Thyroid Gland Carcinoma | 1/45 2% | 17/1592 1% |
| Colorectal Carcinoma | 1/143 1% | 36/3239 1% |
| Osteosarcoma | 2/45 4% | 0/166 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 7/752 1% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 8/810 1% |
| Cervical Carcinoma | 1/35 3% | 3/422 1% |
| Gastric Carcinoma | 0/74 0% | 13/1809 1% |
| Other Solid Cancers | 0/94 0% | 10/1515 1% |
| Other Sarcomas | 2/69 3% | 2/699 0% |
| Esophageal Carcinoma | 0/23 0% | 4/769 1% |
| Biliary Tract Carcinoma | 0/54 0% | 5/950 1% |
| Bladder Carcinoma | 2/58 3% | 3/956 0% |
| Ovarian Carcinoma | 4/109 4% | 1/998 0% |
| Glioma | 0/52 0% | 9/2127 0% |
| Hepatocellular Carcinoma | 0/46 0% | 9/2210 0% |
| Head and Neck Carcinoma | 1/85 1% | 5/1574 0% |
| Breast Carcinoma | 2/144 1% | 8/3264 0% |
| Neuroendocrine Tumour | 0/154 0% | 2/577 0% |
| Kidney Carcinoma | 0/85 0% | 5/1862 0% |
| Pancreatic Carcinoma | 2/89 2% | 2/1611 0% |
| Non-Cancerous | 1/104 1% | 1/830 0% |
| Neuroblastoma | 2/87 2% | 0/1331 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 3/2550 0% |
| Other Blood Cancers | 0/61 0% | 3/2725 0% |
| Prostate Carcinoma | 1/13 8% | 1/2105 0% |
| B-Cell Non-Hodgkins Lymphoma | 0/88 0% | 2/2534 0% |
Mutation Distribution
Where GPC3 is mutated · all tissues, split by cell line vs tissue
How many mutations in GPC3 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 783 mutations in GPC3
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|