Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 356 | 67 | 286 |
| Samples | 190 | 48 | 140 |
| Peptides | 141 | 31 | 115 |
Function
GRAP2 · GRB2 related adaptor protein 2
This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 141 amino-acid changes on canonical ENST00000344138 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in GRAP2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in GRAP2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Endometrial Carcinoma | 2/42 5% | 13/612 2% |
| Melanoma | 5/210 2% | 18/1899 1% |
| Non-Small Cell Lung Carcinoma | 3/304 1% | 15/1390 1% |
| Colorectal Carcinoma | 7/143 5% | 19/3239 1% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 6/810 1% |
| Gastric Carcinoma | 1/74 1% | 10/1809 1% |
| Esophageal Squamous Cell Carcinoma | 3/51 6% | 12/2550 0% |
| Plasma Cell Myeloma | 2/44 5% | 0/305 0% |
| Head and Neck Carcinoma | 4/85 5% | 4/1574 0% |
| Other Sarcomas | 1/69 1% | 2/699 0% |
| Pancreatic Carcinoma | 2/89 2% | 4/1611 0% |
| B-Cell Non-Hodgkins Lymphoma | 5/88 6% | 3/2534 0% |
| Hepatocellular Carcinoma | 2/46 4% | 5/2210 0% |
| Other Solid Cancers | 1/94 1% | 4/1515 0% |
| Bladder Carcinoma | 0/58 0% | 3/956 0% |
| Biliary Tract Carcinoma | 0/54 0% | 3/950 0% |
| Glioma | 0/52 0% | 5/2127 0% |
| Cervical Carcinoma | 0/35 0% | 1/422 0% |
| Ovarian Carcinoma | 0/109 0% | 2/998 0% |
| Kidney Carcinoma | 1/85 1% | 2/1862 0% |
| Neuroblastoma | 0/87 0% | 2/1331 0% |
| Other Blood Cancers | 2/61 3% | 2/2725 0% |
| Neuroendocrine Tumour | 0/154 0% | 1/577 0% |
| Esophageal Carcinoma | 0/23 0% | 1/769 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 1/752 0% |
| B-Lymphoblastic Leukemia | 3/55 5% | 0/2640 0% |
| Prostate Carcinoma | 0/13 0% | 2/2105 0% |
| Thyroid Gland Carcinoma | 1/45 2% | 0/1592 0% |
Mutation Distribution
Where GRAP2 is mutated · all tissues, split by cell line vs tissue
How many mutations in GRAP2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 356 mutations in GRAP2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|