Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 3,152 | 355 | 2,732 |
| Samples | 951 | 161 | 771 |
| Peptides | 789 | 118 | 684 |
Function
GRIK2 · Glutamate ionotropic receptor kainate type subunit 2
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive cognitive disability. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
9 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000421544 | Q13002 | 927 | 635 |
| ENST00000369138 | Q13002-5 | 870 | 594 |
| ENST00000413795 | Q13002-2 | 861 | 587 |
| ENST00000358361 | G3XAD3* | 272 | 187 |
| ENST00000369134 | Q13002 | 166 | 130 |
| ENST00000301218 | Q16478-2 | 48 | 34 |
| ENST00000369137 | A0A0A0MRL4* | 4 | 3 |
| ENST00000262895 | Q16478 | 3 | 3 |
| ENST00000682090 | Q13002 | 1 | 1 |
Gene Properties
Recurrent Mutations
All 635 amino-acid changes on canonical ENST00000421544 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in GRIK2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in GRIK2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Melanoma | 16/210 8% | 126/1899 7% |
| Endometrial Carcinoma | 6/42 14% | 30/612 5% |
| Non-Small Cell Lung Carcinoma | 28/304 9% | 60/1390 4% |
| Chordoma | 0/7 0% | 1/13 8% |
| Colorectal Carcinoma | 29/143 20% | 104/3239 3% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 33/810 4% |
| Small Cell Lung Carcinoma | 2/9 22% | 26/752 3% |
| Gastric Carcinoma | 2/74 3% | 59/1809 3% |
| Other Solid Cancers | 4/94 4% | 48/1515 3% |
| Bladder Carcinoma | 2/58 3% | 29/956 3% |
| Unknown | 1/10 10% | 0/29 0% |
| Thymic Epithelial Tumor | 0/0 0% | 1/39 3% |
| Esophageal Carcinoma | 1/23 4% | 18/769 2% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 57/2550 2% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Cervical Carcinoma | 3/35 9% | 5/422 1% |
| Head and Neck Carcinoma | 3/85 4% | 26/1574 2% |
| Neuroendocrine Tumour | 10/154 6% | 2/577 0% |
| Other Sarcomas | 5/69 7% | 6/699 1% |
| Ovarian Carcinoma | 6/109 6% | 9/998 1% |
| Burkitts Lymphoma | 3/32 9% | 0/196 0% |
| Non-Cancerous | 3/104 3% | 9/830 1% |
| Plasma Cell Myeloma | 3/44 7% | 1/305 0% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Hepatocellular Carcinoma | 0/46 0% | 24/2210 1% |
| Osteosarcoma | 2/45 4% | 0/166 0% |
| Breast Carcinoma | 4/144 3% | 27/3264 1% |
| Mesothelioma | 2/62 3% | 0/165 0% |
Mutation Distribution
Where GRIK2 is mutated · all tissues, split by cell line vs tissue
How many mutations in GRIK2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 3,152 mutations in GRIK2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|