Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 2,486 | 251 | 2,211 |
| Samples | 393 | 77 | 310 |
| Peptides | 335 | 56 | 280 |
Function
GRIN1 · Glutamate ionotropic receptor NMDA type subunit 1
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
7 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 304 amino-acid changes on canonical ENST00000371561 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in GRIN1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in GRIN1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 7/40 18% | 0/0 0% |
| Chronic Myelogenous Leukemia | 4/25 16% | 0/0 0% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Endometrial Carcinoma | 7/42 17% | 11/612 2% |
| Thymic Epithelial Tumor | 0/0 0% | 1/39 3% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Hodgkins Lymphoma | 0/16 0% | 3/122 2% |
| Colorectal Carcinoma | 16/143 11% | 53/3239 2% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Bladder Carcinoma | 2/58 3% | 14/956 1% |
| Melanoma | 2/210 1% | 29/1899 2% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 12/810 1% |
| Non-Small Cell Lung Carcinoma | 9/304 3% | 14/1390 1% |
| Gastric Carcinoma | 4/74 5% | 21/1809 1% |
| Plasma Cell Myeloma | 1/44 2% | 3/305 1% |
| Hepatocellular Carcinoma | 0/46 0% | 21/2210 1% |
| Other Sarcomas | 0/69 0% | 7/699 1% |
| Adrenocortical Carcinoma | 0/3 0% | 1/112 1% |
| Esophageal Squamous Cell Carcinoma | 3/51 6% | 18/2550 1% |
| Biliary Tract Carcinoma | 1/54 2% | 7/950 1% |
| Non-Cancerous | 0/104 0% | 7/830 1% |
| Other Solid Cancers | 1/94 1% | 11/1515 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 12/1592 1% |
| Neuroendocrine Tumour | 0/154 0% | 5/577 1% |
| Cervical Carcinoma | 0/35 0% | 3/422 1% |
| Prostate Carcinoma | 3/13 23% | 11/2105 1% |
| Ovarian Carcinoma | 2/109 2% | 4/998 0% |
| B-Lymphoblastic Leukemia | 9/55 16% | 3/2640 0% |
| Head and Neck Carcinoma | 0/85 0% | 7/1574 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 3/752 0% |
Mutation Distribution
Where GRIN1 is mutated · all tissues, split by cell line vs tissue
How many mutations in GRIN1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 2,486 mutations in GRIN1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|