Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 3,152 | 391 | 2,727 |
| Samples | 987 | 176 | 800 |
| Peptides | 759 | 131 | 649 |
Function
GRM5 · Glutamate metabotropic receptor 5
This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].
Isoforms & Proteins
4 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 702 amino-acid changes on canonical ENST00000305447 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in GRM5 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in GRM5 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 4/25 16% | 0/0 0% |
| T-Lymphoblastic Leukemia | 5/40 12% | 0/0 0% |
| Endometrial Carcinoma | 8/42 19% | 39/612 6% |
| Non-Small Cell Lung Carcinoma | 34/304 11% | 66/1390 5% |
| Squamous Cell Lung Carcinoma | 7/57 12% | 43/810 5% |
| Oral Cavity Carcinoma | 3/54 6% | 0/0 0% |
| Gastric Carcinoma | 2/74 3% | 91/1809 5% |
| Melanoma | 15/210 7% | 71/1899 4% |
| Small Cell Lung Carcinoma | 0/9 0% | 28/752 4% |
| Colorectal Carcinoma | 15/143 10% | 108/3239 3% |
| Other Solid Cancers | 4/94 4% | 51/1515 3% |
| Neuroendocrine Tumour | 17/154 11% | 4/577 1% |
| Adrenocortical Carcinoma | 2/3 67% | 1/112 1% |
| Unknown | 0/10 0% | 1/29 3% |
| Bladder Carcinoma | 1/58 2% | 24/956 3% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Cervical Carcinoma | 1/35 3% | 8/422 2% |
| Osteosarcoma | 4/45 9% | 0/166 0% |
| Esophageal Carcinoma | 0/23 0% | 14/769 2% |
| Ovarian Carcinoma | 6/109 6% | 12/998 1% |
| Germ Cell Tumour | 2/25 8% | 1/169 1% |
| Head and Neck Carcinoma | 2/85 2% | 23/1574 1% |
| Hepatocellular Carcinoma | 3/46 7% | 30/2210 1% |
| Thyroid Gland Carcinoma | 3/45 7% | 18/1592 1% |
| Non-Cancerous | 2/104 2% | 10/830 1% |
| Prostate Carcinoma | 1/13 8% | 25/2105 1% |
| Biliary Tract Carcinoma | 0/54 0% | 12/950 1% |
| Plasma Cell Myeloma | 3/44 7% | 1/305 0% |
| Pancreatic Carcinoma | 6/89 7% | 13/1611 1% |
Mutation Distribution
Where GRM5 is mutated · all tissues, split by cell line vs tissue
How many mutations in GRM5 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 25 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 3,152 mutations in GRM5
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|