Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,729 | 246 | 1,459 |
| Samples | 181 | 34 | 144 |
| Peptides | 186 | 41 | 157 |
Function
GYPA · Glycophorin A (MNS blood group)
Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
13 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000641688 | P02724 | 178 | 83 |
| ENST00000360771 | P02724 | 167 | 82 |
| ENST00000616983 | A0A087WU29* | 163 | 79 |
| ENST00000535709 | A0A087WU29* | 162 | 78 |
| ENST00000642295 | A0A2R8Y7F9* | 149 | 76 |
| ENST00000512064 | E9PD10* | 148 | 72 |
| ENST00000504786 | E7EQF3* | 137 | 59 |
| ENST00000324022 | P02724-3 | 118 | 74 |
| ENST00000503627 | E9PH25* | 118 | 49 |
| ENST00000642713 | P02724-2 | 116 | 72 |
| ENST00000646447 | P02724-2 | 116 | 72 |
| ENST00000512789 | Q13030* | 88 | 51 |
| ENST00000643148 | A0A2R8Y6V6* | 69 | 41 |
Gene Properties
Recurrent Mutations
All 83 amino-acid changes on canonical ENST00000641688 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in GYPA · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in GYPA – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Gastrointestinal Stromal Tumour | 0/0 0% | 5/133 4% |
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Melanoma | 1/210 0% | 27/1899 1% |
| Endometrial Carcinoma | 1/42 2% | 6/612 1% |
| Non-Small Cell Lung Carcinoma | 12/304 4% | 4/1390 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 15/1592 1% |
| Small Cell Lung Carcinoma | 2/9 22% | 5/752 1% |
| Other Solid Cancers | 2/94 2% | 12/1515 1% |
| Colorectal Carcinoma | 4/143 3% | 21/3239 1% |
| Esophageal Carcinoma | 2/23 9% | 3/769 0% |
| Bladder Carcinoma | 0/58 0% | 5/956 1% |
| Hepatocellular Carcinoma | 0/46 0% | 11/2210 0% |
| Gastric Carcinoma | 0/74 0% | 8/1809 0% |
| Head and Neck Carcinoma | 0/85 0% | 6/1574 0% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 2/810 0% |
| Cervical Carcinoma | 0/35 0% | 1/422 0% |
| B-Cell Non-Hodgkins Lymphoma | 2/88 2% | 2/2534 0% |
| Other Blood Cancers | 0/61 0% | 4/2725 0% |
| Neuroendocrine Tumour | 0/154 0% | 1/577 0% |
| Prostate Carcinoma | 2/13 15% | 1/2105 0% |
| Glioma | 1/52 2% | 2/2127 0% |
| Other Sarcomas | 0/69 0% | 1/699 0% |
| B-Lymphoblastic Leukemia | 1/55 2% | 2/2640 0% |
| Biliary Tract Carcinoma | 0/54 0% | 1/950 0% |
| Kidney Carcinoma | 1/85 1% | 1/1862 0% |
| Pancreatic Carcinoma | 0/89 0% | 1/1611 0% |
Mutation Distribution
Where GYPA is mutated · all tissues, split by cell line vs tissue
How many mutations in GYPA were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 26 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,729 mutations in GYPA
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|