Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 46 | 39 | 0 |
| Samples | 44 | 38 | 0 |
| Peptides | 40 | 36 | 0 |
Function
H1-5 · H1.5 linker histone, cluster member
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000331442 | P16401 | 46 | 40 |
Gene Properties
Recurrent Mutations
All 40 amino-acid changes on canonical ENST00000331442 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in H1-5 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in H1-5 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Chronic Myelogenous Leukemia | 1/25 4% | 0/0 0% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Hodgkins Lymphoma | 2/16 12% | 0/122 0% |
| Rhabdomyosarcoma | 2/33 6% | 0/171 0% |
| Ovarian Carcinoma | 3/109 3% | 2/998 0% |
| Burkitts Lymphoma | 1/32 3% | 0/196 0% |
| Endometrial Carcinoma | 1/42 2% | 1/612 0% |
| Plasma Cell Myeloma | 1/44 2% | 0/305 0% |
| Colorectal Carcinoma | 6/143 4% | 2/3239 0% |
| Other Solid Cancers | 2/94 2% | 1/1515 0% |
| B-Cell Non-Hodgkins Lymphoma | 5/88 6% | 0/2534 0% |
| Neuroendocrine Tumour | 1/154 1% | 0/577 0% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 0/810 0% |
| Melanoma | 2/210 1% | 0/1899 0% |
| Esophageal Squamous Cell Carcinoma | 2/51 4% | 0/2550 0% |
| Non-Small Cell Lung Carcinoma | 1/304 0% | 0/1390 0% |
| Head and Neck Carcinoma | 1/85 1% | 0/1574 0% |
| Prostate Carcinoma | 1/13 8% | 0/2105 0% |
| Other Blood Cancers | 1/61 2% | 0/2725 0% |
Mutation Distribution
Where H1-5 is mutated · all tissues, split by cell line vs tissue
How many mutations in H1-5 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 46 mutations in H1-5
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|