Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 3,040 | 354 | 2,645 |
| Samples | 779 | 137 | 633 |
| Peptides | 624 | 97 | 555 |
Function
HGF · Hepatocyte growth factor
This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015].
Isoforms & Proteins
8 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000222390 | P14210 | 856 | 563 |
| ENST00000457544 | P14210-3 | 765 | 540 |
| ENST00000444829 | P14210-2 | 349 | 227 |
| ENST00000453411 | P14210-5 | 343 | 224 |
| ENST00000423064 | P14210-6 | 231 | 151 |
| ENST00000465234 | A0A2R8YEI1* | 225 | 148 |
| ENST00000354224 | C9WSJ3* | 136 | 107 |
| ENST00000643024 | A0A2R8YF76* | 135 | 106 |
Gene Properties
Recurrent Mutations
All 563 amino-acid changes on canonical ENST00000222390 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in HGF · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in HGF – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 5/40 12% | 0/0 0% |
| Melanoma | 26/210 12% | 108/1899 6% |
| Non-Small Cell Lung Carcinoma | 20/304 7% | 77/1390 6% |
| Oral Cavity Carcinoma | 3/54 6% | 0/0 0% |
| Chordoma | 0/7 0% | 1/13 8% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 35/810 4% |
| Endometrial Carcinoma | 5/42 12% | 20/612 3% |
| Other Solid Cancers | 0/94 0% | 51/1515 3% |
| Small Cell Lung Carcinoma | 4/9 44% | 20/752 3% |
| Glioblastoma | 3/98 3% | 0/0 0% |
| Gastric Carcinoma | 3/74 4% | 42/1809 2% |
| Bladder Carcinoma | 4/58 7% | 19/956 2% |
| Colorectal Carcinoma | 9/143 6% | 61/3239 2% |
| Cervical Carcinoma | 0/35 0% | 8/422 2% |
| Esophageal Squamous Cell Carcinoma | 8/51 16% | 37/2550 1% |
| Neuroendocrine Tumour | 8/154 5% | 4/577 1% |
| Other Sarcomas | 4/69 6% | 8/699 1% |
| Germ Cell Tumour | 1/25 4% | 2/169 1% |
| Rhabdomyosarcoma | 2/33 6% | 1/171 1% |
| Plasma Cell Myeloma | 4/44 9% | 1/305 0% |
| Hepatocellular Carcinoma | 2/46 4% | 28/2210 1% |
| Burkitts Lymphoma | 3/32 9% | 0/196 0% |
| Esophageal Carcinoma | 0/23 0% | 8/769 1% |
| Non-Cancerous | 0/104 0% | 9/830 1% |
| Head and Neck Carcinoma | 2/85 2% | 12/1574 1% |
| B-Cell Non-Hodgkins Lymphoma | 3/88 3% | 18/2534 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Pancreatic Carcinoma | 0/89 0% | 12/1611 1% |
| Medulloblastoma | 0/0 0% | 3/450 1% |
Mutation Distribution
Where HGF is mutated · all tissues, split by cell line vs tissue
How many mutations in HGF were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 3,040 mutations in HGF
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|