Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 761 | 102 | 650 |
| Samples | 518 | 87 | 423 |
| Peptides | 403 | 63 | 353 |
Function
HHIP · Hedgehog interacting protein
This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height.[provided by RefSeq, Feb 2011].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 388 amino-acid changes on canonical ENST00000296575 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in HHIP · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in HHIP – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Chordoma | 0/7 0% | 1/13 8% |
| Endometrial Carcinoma | 5/42 12% | 26/612 4% |
| Melanoma | 9/210 4% | 83/1899 4% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Other Solid Cancers | 0/94 0% | 35/1515 2% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 17/810 2% |
| Colorectal Carcinoma | 17/143 12% | 50/3239 2% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Gastric Carcinoma | 1/74 1% | 32/1809 2% |
| Pheochromocytoma and Paraganglioma | 0/0 0% | 1/71 1% |
| Non-Small Cell Lung Carcinoma | 7/304 2% | 16/1390 1% |
| Bladder Carcinoma | 1/58 2% | 12/956 1% |
| Ovarian Carcinoma | 6/109 6% | 7/998 1% |
| Plasma Cell Myeloma | 2/44 5% | 2/305 1% |
| Hepatocellular Carcinoma | 0/46 0% | 25/2210 1% |
| Cervical Carcinoma | 2/35 6% | 3/422 1% |
| Germ Cell Tumour | 2/25 8% | 0/169 0% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Rhabdomyosarcoma | 2/33 6% | 0/171 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 7/752 1% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 22/2550 1% |
| Head and Neck Carcinoma | 0/85 0% | 13/1574 1% |
| Thyroid Gland Carcinoma | 5/45 11% | 6/1592 0% |
| B-Cell Non-Hodgkins Lymphoma | 4/88 5% | 13/2534 1% |
| Other Sarcomas | 2/69 3% | 3/699 0% |
| Biliary Tract Carcinoma | 2/54 4% | 4/950 0% |
| Non-Cancerous | 1/104 1% | 4/830 0% |
| Prostate Carcinoma | 2/13 15% | 9/2105 0% |
Mutation Distribution
Where HHIP is mutated · all tissues, split by cell line vs tissue
How many mutations in HHIP were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 761 mutations in HHIP
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|