Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 335 | 52 | 281 |
| Samples | 244 | 39 | 204 |
| Peptides | 211 | 33 | 186 |
Function
HIRIP3 · HIRA interacting protein 3
The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Aug 2011].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 188 amino-acid changes on canonical ENST00000279392 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in HIRIP3 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in HIRIP3 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 5/40 12% | 0/0 0% |
| Hodgkins Lymphoma | 1/16 6% | 2/122 2% |
| Endometrial Carcinoma | 1/42 2% | 13/612 2% |
| Colorectal Carcinoma | 7/143 5% | 34/3239 1% |
| Bladder Carcinoma | 0/58 0% | 12/956 1% |
| Melanoma | 0/210 0% | 21/1899 1% |
| Burkitts Lymphoma | 0/32 0% | 2/196 1% |
| Non-Small Cell Lung Carcinoma | 6/304 2% | 8/1390 1% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 7/810 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Gastric Carcinoma | 0/74 0% | 14/1809 1% |
| Cervical Carcinoma | 0/35 0% | 3/422 1% |
| Neuroendocrine Tumour | 2/154 1% | 2/577 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 9/1592 1% |
| Ovarian Carcinoma | 3/109 3% | 3/998 0% |
| Other Solid Cancers | 0/94 0% | 8/1515 1% |
| Biliary Tract Carcinoma | 0/54 0% | 5/950 1% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 10/2550 0% |
| Glioma | 0/52 0% | 9/2127 0% |
| Breast Carcinoma | 4/144 3% | 9/3264 0% |
| Hepatocellular Carcinoma | 1/46 2% | 6/2210 0% |
| Head and Neck Carcinoma | 0/85 0% | 5/1574 0% |
| Plasma Cell Myeloma | 0/44 0% | 1/305 0% |
| Other Sarcomas | 2/69 3% | 0/699 0% |
| Other Blood Cancers | 0/61 0% | 7/2725 0% |
| Non-Cancerous | 0/104 0% | 2/830 0% |
| Pancreatic Carcinoma | 0/89 0% | 3/1611 0% |
| Kidney Carcinoma | 0/85 0% | 3/1862 0% |
| B-Cell Non-Hodgkins Lymphoma | 1/88 1% | 3/2534 0% |
| Prostate Carcinoma | 1/13 8% | 2/2105 0% |
Mutation Distribution
Where HIRIP3 is mutated · all tissues, split by cell line vs tissue
How many mutations in HIRIP3 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 335 mutations in HIRIP3
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|