Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 4,127 | 515 | 3,501 |
| Samples | 1,216 | 232 | 973 |
| Peptides | 1,033 | 159 | 872 |
Function
HIVEP3 · HIVEP zinc finger 3
This gene encodes a member of the human immunodeficiency virus type 1 enhancer-binding protein family. Members of this protein family contain multiple zinc finger and acid-rich (ZAS) domains and serine-threonine rich regions. This protein acts as a transcription factor and is able to regulate nuclear factor kappaB-mediated transcription by binding the kappaB motif in target genes. This protein also binds the recombination signal sequence that flanks the V, D, and J regions of immunoglobulin and T-cell receptors. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Sep 2011].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 1024 amino-acid changes on canonical ENST00000372583 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in HIVEP3 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in HIVEP3 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Endometrial Carcinoma | 9/42 21% | 46/612 8% |
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| Melanoma | 13/210 6% | 151/1899 8% |
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Other Solid Cancers | 6/94 6% | 83/1515 5% |
| Hodgkins Lymphoma | 5/16 31% | 2/122 2% |
| Non-Small Cell Lung Carcinoma | 32/304 11% | 49/1390 4% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 6/133 5% |
| Acute Myeloid Leukemia | 4/90 4% | 0/0 0% |
| Colorectal Carcinoma | 25/143 17% | 122/3239 4% |
| Gastric Carcinoma | 5/74 7% | 74/1809 4% |
| Cervical Carcinoma | 6/35 17% | 13/422 3% |
| Glioblastoma | 4/98 4% | 0/0 0% |
| Bladder Carcinoma | 4/58 7% | 34/956 4% |
| Squamous Cell Lung Carcinoma | 5/57 9% | 26/810 3% |
| Germ Cell Tumour | 3/25 12% | 3/169 2% |
| Ovarian Carcinoma | 12/109 11% | 20/998 2% |
| Plasma Cell Myeloma | 1/44 2% | 8/305 3% |
| Neuroendocrine Tumour | 10/154 6% | 7/577 1% |
| Mesothelioma | 2/62 3% | 3/165 2% |
| Ewings Sarcoma | 3/63 5% | 4/262 2% |
| Small Cell Lung Carcinoma | 1/9 11% | 15/752 2% |
| Esophageal Carcinoma | 2/23 9% | 14/769 2% |
| Hepatocellular Carcinoma | 5/46 11% | 38/2210 2% |
| Burkitts Lymphoma | 3/32 9% | 1/196 1% |
| Adrenocortical Carcinoma | 2/3 67% | 0/112 0% |
| Thyroid Gland Carcinoma | 3/45 7% | 25/1592 2% |
| Glioma | 5/52 10% | 31/2127 1% |
| Esophageal Squamous Cell Carcinoma | 8/51 16% | 34/2550 1% |
| Non-Cancerous | 1/104 1% | 14/830 2% |
Mutation Distribution
Where HIVEP3 is mutated · all tissues, split by cell line vs tissue
How many mutations in HIVEP3 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 4,127 mutations in HIVEP3
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|