Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 522 | 78 | 437 |
| Samples | 305 | 60 | 240 |
| Peptides | 204 | 44 | 161 |
Function
HNRNPL · Heterogeneous nuclear ribonucleoprotein L
Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 203 amino-acid changes on canonical ENST00000221419 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in HNRNPL · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in HNRNPL – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 5/40 12% | 0/0 0% |
| Glioblastoma | 5/98 5% | 0/0 0% |
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Endometrial Carcinoma | 5/42 12% | 15/612 2% |
| Other Solid Cancers | 0/94 0% | 29/1515 2% |
| Colorectal Carcinoma | 9/143 6% | 35/3239 1% |
| Melanoma | 3/210 1% | 24/1899 1% |
| Bladder Carcinoma | 4/58 7% | 8/956 1% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 29/2550 1% |
| Gastric Carcinoma | 2/74 3% | 13/1809 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Non-Small Cell Lung Carcinoma | 4/304 1% | 8/1390 1% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 5/810 1% |
| Ewings Sarcoma | 1/63 2% | 1/262 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 10/1592 1% |
| Plasma Cell Myeloma | 0/44 0% | 2/305 1% |
| Rhabdomyosarcoma | 0/33 0% | 1/171 1% |
| Hepatocellular Carcinoma | 0/46 0% | 11/2210 0% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
| Glioma | 0/52 0% | 10/2127 0% |
| Mesothelioma | 1/62 2% | 0/165 0% |
| Cervical Carcinoma | 0/35 0% | 2/422 0% |
| Non-Cancerous | 1/104 1% | 3/830 0% |
| Neuroendocrine Tumour | 3/154 2% | 0/577 0% |
| Biliary Tract Carcinoma | 2/54 4% | 2/950 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 3/752 0% |
| Breast Carcinoma | 2/144 1% | 9/3264 0% |
| Head and Neck Carcinoma | 0/85 0% | 5/1574 0% |
| Ovarian Carcinoma | 2/109 2% | 1/998 0% |
| Kidney Carcinoma | 2/85 2% | 3/1862 0% |
Mutation Distribution
Where HNRNPL is mutated · all tissues, split by cell line vs tissue
How many mutations in HNRNPL were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 522 mutations in HNRNPL
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|