Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 304 | 39 | 252 |
| Samples | 294 | 39 | 242 |
| Peptides | 184 | 30 | 155 |
Function
HTR6 · 5-hydroxytryptamine receptor 6
This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000289753 | P50406 | 304 | 184 |
Gene Properties
Recurrent Mutations
All 184 amino-acid changes on canonical ENST00000289753 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in HTR6 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in HTR6 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Other Solid Cancers | 2/94 2% | 46/1515 3% |
| Thymic Epithelial Tumor | 0/0 0% | 1/39 3% |
| Cervical Carcinoma | 2/35 6% | 7/422 2% |
| Melanoma | 4/210 2% | 28/1899 1% |
| Endometrial Carcinoma | 2/42 5% | 7/612 1% |
| Biliary Tract Carcinoma | 0/54 0% | 12/950 1% |
| Gastric Carcinoma | 2/74 3% | 20/1809 1% |
| Non-Small Cell Lung Carcinoma | 0/304 0% | 19/1390 1% |
| Bladder Carcinoma | 2/58 3% | 9/956 1% |
| Colorectal Carcinoma | 2/143 1% | 34/3239 1% |
| Plasma Cell Myeloma | 3/44 7% | 0/305 0% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 4/810 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Thyroid Gland Carcinoma | 2/45 4% | 10/1592 1% |
| Head and Neck Carcinoma | 2/85 2% | 9/1574 1% |
| Non-Cancerous | 0/104 0% | 6/830 1% |
| Neuroendocrine Tumour | 4/154 3% | 0/577 0% |
| Hepatocellular Carcinoma | 0/46 0% | 12/2210 1% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Rhabdomyosarcoma | 1/33 3% | 0/171 0% |
| Other Sarcomas | 0/69 0% | 3/699 0% |
| Esophageal Carcinoma | 0/23 0% | 3/769 0% |
| Ovarian Carcinoma | 0/109 0% | 3/998 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 2/752 0% |
| Medulloblastoma | 0/0 0% | 1/450 0% |
| Kidney Carcinoma | 1/85 1% | 3/1862 0% |
| Prostate Carcinoma | 1/13 8% | 3/2105 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 4/2550 0% |
| B-Cell Non-Hodgkins Lymphoma | 1/88 1% | 3/2534 0% |
Mutation Distribution
Where HTR6 is mutated · all tissues, split by cell line vs tissue
How many mutations in HTR6 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 49 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 304 mutations in HTR6
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|