Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 518 | 93 | 419 |
| Samples | 354 | 72 | 277 |
| Peptides | 284 | 46 | 236 |
Function
IDE · Insulin degrading enzyme
This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.[provided by RefSeq, Sep 2009].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 282 amino-acid changes on canonical ENST00000265986 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in IDE · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in IDE – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 5/40 12% | 0/0 0% |
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| Oral Cavity Carcinoma | 4/54 7% | 0/0 0% |
| Endometrial Carcinoma | 7/42 17% | 18/612 3% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Bladder Carcinoma | 5/58 9% | 11/956 1% |
| Melanoma | 6/210 3% | 27/1899 1% |
| Cervical Carcinoma | 0/35 0% | 7/422 2% |
| Colorectal Carcinoma | 13/143 9% | 33/3239 1% |
| Non-Small Cell Lung Carcinoma | 6/304 2% | 17/1390 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 10/752 1% |
| Other Solid Cancers | 0/94 0% | 17/1515 1% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 23/2550 1% |
| Gastric Carcinoma | 4/74 5% | 12/1809 1% |
| Other Sarcomas | 0/69 0% | 6/699 1% |
| Head and Neck Carcinoma | 2/85 2% | 11/1574 1% |
| Esophageal Carcinoma | 0/23 0% | 6/769 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Neuroendocrine Tumour | 1/154 1% | 4/577 1% |
| Thyroid Gland Carcinoma | 1/45 2% | 10/1592 1% |
| Hepatocellular Carcinoma | 0/46 0% | 14/2210 1% |
| Biliary Tract Carcinoma | 0/54 0% | 6/950 1% |
| Plasma Cell Myeloma | 1/44 2% | 1/305 0% |
| Ovarian Carcinoma | 2/109 2% | 4/998 0% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Breast Carcinoma | 0/144 0% | 15/3264 0% |
| Burkitts Lymphoma | 0/32 0% | 1/196 1% |
| Mesothelioma | 0/62 0% | 1/165 1% |
| Glioma | 0/52 0% | 9/2127 0% |
| Meningioma | 1/3 33% | 0/252 0% |
Mutation Distribution
Where IDE is mutated · all tissues, split by cell line vs tissue
How many mutations in IDE were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 518 mutations in IDE
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|