Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,839 | 320 | 1,491 |
| Samples | 724 | 155 | 558 |
| Peptides | 629 | 118 | 521 |
Function
IL16 · Interleukin 16
The protein encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. The signaling process of this cytokine is mediated by CD4. The product of this gene undergoes proteolytic processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is reported to be involved in the proteolytic processing of this protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010].
Isoforms & Proteins
5 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000683961 | Q14005 | 755 | 540 |
| ENST00000394660 | Q14005-2 | 724 | 556 |
| ENST00000394652 | Q14005-3 | 308 | 238 |
| ENST00000302987 | A0A8C8KBU6* | 51 | 43 |
| ENST00000560241 | H0YKB7* | 1 | 1 |
Gene Properties
Recurrent Mutations
All 540 amino-acid changes on canonical ENST00000683961 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in IL16 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in IL16 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 7/40 18% | 0/0 0% |
| Chronic Myelogenous Leukemia | 4/25 16% | 0/0 0% |
| Oral Cavity Carcinoma | 3/54 6% | 0/0 0% |
| Endometrial Carcinoma | 4/42 10% | 31/612 5% |
| Glioblastoma | 5/98 5% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 28/304 9% | 49/1390 4% |
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Melanoma | 6/210 3% | 75/1899 4% |
| Colorectal Carcinoma | 21/143 15% | 81/3239 2% |
| Other Solid Cancers | 6/94 6% | 38/1515 3% |
| Neuroendocrine Tumour | 11/154 7% | 8/577 1% |
| Gastric Carcinoma | 4/74 5% | 38/1809 2% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Squamous Cell Lung Carcinoma | 4/57 7% | 13/810 2% |
| Bladder Carcinoma | 1/58 2% | 18/956 2% |
| Ovarian Carcinoma | 3/109 3% | 14/998 1% |
| Ewings Sarcoma | 4/63 6% | 1/262 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 2/133 2% |
| Hodgkins Lymphoma | 0/16 0% | 2/122 2% |
| Osteosarcoma | 3/45 7% | 0/166 0% |
| Burkitts Lymphoma | 2/32 6% | 1/196 1% |
| Cervical Carcinoma | 0/35 0% | 6/422 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 10/752 1% |
| Neuroblastoma | 6/87 7% | 10/1331 1% |
| Glioma | 2/52 4% | 21/2127 1% |
| Esophageal Squamous Cell Carcinoma | 5/51 10% | 21/2550 1% |
| Biliary Tract Carcinoma | 1/54 2% | 9/950 1% |
| Rhabdomyosarcoma | 0/33 0% | 2/171 1% |
| Head and Neck Carcinoma | 1/85 1% | 15/1574 1% |
| Hepatocellular Carcinoma | 1/46 2% | 20/2210 1% |
Mutation Distribution
Where IL16 is mutated · all tissues, split by cell line vs tissue
How many mutations in IL16 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,839 mutations in IL16
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|