Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 874 | 168 | 700 |
| Samples | 455 | 112 | 339 |
| Peptides | 345 | 83 | 273 |
Function
IL17RA · Interleukin 17 receptor A
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 337 amino-acid changes on canonical ENST00000319363 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in IL17RA · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in IL17RA – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chordoma | 2/7 29% | 0/13 0% |
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Acute Myeloid Leukemia | 3/90 3% | 0/0 0% |
| Endometrial Carcinoma | 10/42 24% | 11/612 2% |
| Glioblastoma | 3/98 3% | 0/0 0% |
| Melanoma | 8/210 4% | 36/1899 2% |
| Gastric Carcinoma | 6/74 8% | 32/1809 2% |
| Cervical Carcinoma | 3/35 9% | 6/422 1% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Adrenocortical Carcinoma | 2/3 67% | 0/112 0% |
| Non-Small Cell Lung Carcinoma | 11/304 4% | 18/1390 1% |
| Non-Cancerous | 2/104 2% | 14/830 2% |
| Colorectal Carcinoma | 9/143 6% | 46/3239 1% |
| Other Sarcomas | 6/69 9% | 6/699 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 2/133 2% |
| Other Solid Cancers | 3/94 3% | 20/1515 1% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 10/810 1% |
| Bladder Carcinoma | 1/58 2% | 9/956 1% |
| Neuroendocrine Tumour | 5/154 3% | 2/577 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 7/752 1% |
| Burkitts Lymphoma | 1/32 3% | 1/196 1% |
| Glioma | 2/52 4% | 14/2127 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 12/1592 1% |
| Head and Neck Carcinoma | 1/85 1% | 11/1574 1% |
| Biliary Tract Carcinoma | 2/54 4% | 5/950 1% |
| Medulloblastoma | 0/0 0% | 3/450 1% |
| Ewings Sarcoma | 1/63 2% | 1/262 0% |
| Esophageal Squamous Cell Carcinoma | 2/51 4% | 14/2550 1% |
| Prostate Carcinoma | 3/13 23% | 9/2105 0% |
Mutation Distribution
Where IL17RA is mutated · all tissues, split by cell line vs tissue
How many mutations in IL17RA were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 874 mutations in IL17RA
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|