Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 106 | 27 | 79 |
| Samples | 105 | 27 | 78 |
| Peptides | 74 | 16 | 60 |
Function
IL2 · Interleukin 2
This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Sep 2020].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000226730 | P60568 | 106 | 74 |
Gene Properties
Recurrent Mutations
All 74 amino-acid changes on canonical ENST00000226730 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in IL2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in IL2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Melanoma | 4/210 2% | 21/1899 1% |
| Endometrial Carcinoma | 1/42 2% | 6/612 1% |
| Burkitts Lymphoma | 2/32 6% | 0/196 0% |
| Non-Small Cell Lung Carcinoma | 0/304 0% | 10/1390 1% |
| Neuroendocrine Tumour | 2/154 1% | 1/577 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 3/752 0% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 0/810 0% |
| Colorectal Carcinoma | 2/143 1% | 10/3239 0% |
| Non-Cancerous | 0/104 0% | 3/830 0% |
| Gastric Carcinoma | 2/74 3% | 4/1809 0% |
| Biliary Tract Carcinoma | 1/54 2% | 2/950 0% |
| Other Solid Cancers | 0/94 0% | 4/1515 0% |
| Bladder Carcinoma | 0/58 0% | 2/956 0% |
| Head and Neck Carcinoma | 1/85 1% | 2/1574 0% |
| Ovarian Carcinoma | 1/109 1% | 1/998 0% |
| Esophageal Carcinoma | 1/23 4% | 0/769 0% |
| Hepatocellular Carcinoma | 0/46 0% | 3/2210 0% |
| Kidney Carcinoma | 0/85 0% | 2/1862 0% |
| Prostate Carcinoma | 2/13 15% | 0/2105 0% |
| Breast Carcinoma | 2/144 1% | 1/3264 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 2/2550 0% |
| Pancreatic Carcinoma | 1/89 1% | 0/1611 0% |
| Glioma | 0/52 0% | 1/2127 0% |
Mutation Distribution
Where IL2 is mutated · all tissues, split by cell line vs tissue
How many mutations in IL2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 16 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 106 mutations in IL2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|