Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,177 | 134 | 1,035 |
| Samples | 399 | 68 | 327 |
| Peptides | 290 | 44 | 254 |
Function
IL21R · Interleukin 21 receptor
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 290 amino-acid changes on canonical ENST00000337929 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in IL21R · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in IL21R – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Melanoma | 9/210 4% | 71/1899 4% |
| Endometrial Carcinoma | 2/42 5% | 20/612 3% |
| T-Lymphoblastic Leukemia | 1/40 2% | 0/0 0% |
| Hodgkins Lymphoma | 3/16 19% | 0/122 0% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 4/304 1% | 24/1390 2% |
| Small Cell Lung Carcinoma | 0/9 0% | 11/752 1% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 11/810 1% |
| Other Solid Cancers | 3/94 3% | 17/1515 1% |
| Colorectal Carcinoma | 9/143 6% | 32/3239 1% |
| Gastric Carcinoma | 2/74 3% | 19/1809 1% |
| Hepatocellular Carcinoma | 2/46 4% | 23/2210 1% |
| Ovarian Carcinoma | 5/109 5% | 7/998 1% |
| Ewings Sarcoma | 2/63 3% | 1/262 0% |
| Neuroendocrine Tumour | 4/154 3% | 2/577 0% |
| Bladder Carcinoma | 0/58 0% | 8/956 1% |
| Other Sarcomas | 2/69 3% | 4/699 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Esophageal Squamous Cell Carcinoma | 4/51 8% | 14/2550 1% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Esophageal Carcinoma | 1/23 4% | 3/769 0% |
| Head and Neck Carcinoma | 0/85 0% | 8/1574 1% |
| Osteosarcoma | 0/45 0% | 1/166 1% |
| Cervical Carcinoma | 0/35 0% | 2/422 0% |
| Non-Cancerous | 0/104 0% | 4/830 0% |
| Kidney Carcinoma | 1/85 1% | 7/1862 0% |
| Biliary Tract Carcinoma | 2/54 4% | 2/950 0% |
| Breast Carcinoma | 2/144 1% | 10/3264 0% |
| B-Cell Non-Hodgkins Lymphoma | 4/88 5% | 4/2534 0% |
Mutation Distribution
Where IL21R is mutated · all tissues, split by cell line vs tissue
How many mutations in IL21R were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,177 mutations in IL21R
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|