IL32 Interleukin 32 P24001 IL32_HUMAN
Protein Coding Chr 16 16p13.3 Swiss-Prot reviewed Entrez 9235
Mutations
3,485
CL 248 · Tissue 2,942
Samples
148
CL 17 · Tissue 122
Peptides
162
unique mutant peptides
Transcripts
27
isoforms mutated

Stats by Source

Global, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)

How the counts split by source
Stats by Source

Global = all mutations for this gene across every source.

Cell line = COSMIC Cell Lines Project + DepMap + PubMed.

Tissue = COSMIC primary-tissue (patient tumour) samples.

Global can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.

GlobalCell lineTissue
Mutations3,4852482,942
Samples14817122
Peptides16225121

Function

IL32 · Interleukin 32

This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

Isoforms & Proteins

27 transcripts · UniProt mapping is sequence-verified (AA-safe)

About the isoform mapping
Isoforms & Proteins

Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.

The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.

Counts are mutations and unique mutant peptides on each transcript.

TranscriptUniProtMutationsPeptides
ENST00000396890 P24001 150 92
ENST00000534507 P24001 150 92
ENST00000548476 P24001 150 92
ENST00000551513 F8VVN4* 148 90
ENST00000552936 F8W1V1* 141 84
ENST00000525643 P24001-2 138 81
ENST00000530538 P24001-2 133 80
ENST00000325568 P24001-2 132 79
ENST00000440815 P24001-2 132 79
ENST00000444393 P24001-2 132 79
ENST00000526464 P24001-2 132 79
ENST00000528163 P24001-2 132 79
ENST00000529550 P24001-2 132 79
ENST00000533097 P24001-2 132 79
ENST00000552664 P24001-2 132 79
ENST00000382213 P24001-6 130 77
ENST00000548652 P24001-6 130 77
ENST00000531965 P24001-3 128 75
ENST00000529699 C6GKH1* 126 73
ENST00000613483 C6GKH1* 126 73
ENST00000008180 P24001-5 119 70
ENST00000530890 P24001-5 119 70
ENST00000552356 P24001-5 119 70
ENST00000548246 P24001-7 113 64
ENST00000396887 P24001-4 103 57
ENST00000549213 P24001-4 103 57
ENST00000551122 P24001-4 103 57

Gene Properties

Type
Protein Coding
Chromosome
16
Cytoband
16p13.3
Entrez ID
9235
Aliases
IL-32alphaIL-32betaIL-32deltaIL-32gammaNK4TAIF

Recurrent Mutations

Top recurrent amino-acid changes along the protein · needle height = number of mutations

What this lollipop shows
Recurrent Mutations

A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).

X-axis = amino-acid position in the protein.

Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.

The most recurrent changes are labelled; hover any needle for the change, position and counts.

Mutation Distribution

Where IL32 is mutated · all tissues, split by cell line vs tissue

Mutation counts by tissue
Mutation Distribution

How many mutations in IL32 were found in each tissue, across the whole database.

Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.

This shows the cancer-context where this gene is recurrently altered.

GTEx Expression

Median TPM across 54 healthy tissues

GTEx Portal ↗
About the expression data
GTEx Expression

Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.

Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.

Scroll or drag the mini-axis below the chart to browse all tissues.

Mutations

All 3,485 mutations in IL32

About the mutation list
Mutations

Every mutation record for this gene, across all samples and sources.

The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).

Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.

IDSampleTranscriptAA Change CDSTypeSourcePeptide