Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 647 | 104 | 533 |
| Samples | 282 | 60 | 218 |
| Peptides | 210 | 45 | 172 |
Function
IL6R · Interleukin 6 receptor
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been identified in this gene. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, Aug 2020].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000368485 | P08887 | 283 | 192 |
| ENST00000344086 | P08887-2 | 196 | 145 |
| ENST00000622330 | A0A087WTB5* | 168 | 129 |
Gene Properties
Recurrent Mutations
All 192 amino-acid changes on canonical ENST00000368485 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in IL6R · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in IL6R – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 4/133 3% |
| Endometrial Carcinoma | 2/42 5% | 11/612 2% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Neuroendocrine Tumour | 3/154 2% | 9/577 2% |
| Melanoma | 4/210 2% | 22/1899 1% |
| Plasma Cell Myeloma | 1/44 2% | 3/305 1% |
| Cervical Carcinoma | 2/35 6% | 3/422 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 17/1592 1% |
| Colorectal Carcinoma | 11/143 8% | 22/3239 1% |
| Rhabdomyosarcoma | 1/33 3% | 1/171 1% |
| Non-Small Cell Lung Carcinoma | 3/304 1% | 13/1390 1% |
| Ovarian Carcinoma | 7/109 6% | 3/998 0% |
| Bladder Carcinoma | 2/58 3% | 7/956 1% |
| Other Solid Cancers | 1/94 1% | 13/1515 1% |
| Gastric Carcinoma | 0/74 0% | 16/1809 1% |
| Kidney Carcinoma | 2/85 2% | 11/1862 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 5/752 1% |
| Hepatocellular Carcinoma | 0/46 0% | 14/2210 1% |
| Germ Cell Tumour | 0/25 0% | 1/169 1% |
| Biliary Tract Carcinoma | 1/54 2% | 4/950 0% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 2/810 0% |
| Other Sarcomas | 0/69 0% | 3/699 0% |
| Meningioma | 1/3 33% | 0/252 0% |
| Head and Neck Carcinoma | 0/85 0% | 6/1574 0% |
| Pancreatic Carcinoma | 2/89 2% | 4/1611 0% |
| Breast Carcinoma | 5/144 3% | 7/3264 0% |
| Ewings Sarcoma | 0/63 0% | 1/262 0% |
| Esophageal Squamous Cell Carcinoma | 3/51 6% | 5/2550 0% |
Mutation Distribution
Where IL6R is mutated · all tissues, split by cell line vs tissue
How many mutations in IL6R were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 647 mutations in IL6R
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|