Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,272 | 161 | 1,097 |
| Samples | 377 | 73 | 299 |
| Peptides | 341 | 50 | 287 |
Function
IL6ST · Interleukin 6 cytokine family signal transducer
The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014].
Isoforms & Proteins
6 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 302 amino-acid changes on canonical ENST00000381298 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in IL6ST · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in IL6ST – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 5/40 12% | 0/0 0% |
| Endometrial Carcinoma | 2/42 5% | 21/612 3% |
| Plasma Cell Myeloma | 5/44 11% | 5/305 2% |
| Cervical Carcinoma | 2/35 6% | 6/422 1% |
| Melanoma | 1/210 0% | 36/1899 2% |
| Bladder Carcinoma | 2/58 3% | 15/956 2% |
| Germ Cell Tumour | 2/25 8% | 1/169 1% |
| Colorectal Carcinoma | 11/143 8% | 41/3239 1% |
| Other Solid Cancers | 1/94 1% | 17/1515 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Neuroendocrine Tumour | 4/154 3% | 4/577 1% |
| Other Sarcomas | 0/69 0% | 8/699 1% |
| Hepatocellular Carcinoma | 2/46 4% | 21/2210 1% |
| Gastric Carcinoma | 2/74 3% | 15/1809 1% |
| Mesothelioma | 2/62 3% | 0/165 0% |
| Burkitts Lymphoma | 2/32 6% | 0/196 0% |
| Adrenocortical Carcinoma | 1/3 33% | 0/112 0% |
| Head and Neck Carcinoma | 1/85 1% | 12/1574 1% |
| Ovarian Carcinoma | 5/109 5% | 3/998 0% |
| Biliary Tract Carcinoma | 1/54 2% | 6/950 1% |
| Breast Carcinoma | 1/144 1% | 21/3264 1% |
| Non-Small Cell Lung Carcinoma | 3/304 1% | 8/1390 1% |
| Thyroid Gland Carcinoma | 1/45 2% | 9/1592 1% |
| Kidney Carcinoma | 2/85 2% | 8/1862 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 4/810 0% |
| Prostate Carcinoma | 3/13 23% | 6/2105 0% |
| Meningioma | 1/3 33% | 0/252 0% |
| Esophageal Carcinoma | 0/23 0% | 3/769 0% |
| B-Lymphoblastic Leukemia | 5/55 9% | 4/2640 0% |
| Glioma | 1/52 2% | 6/2127 0% |
Mutation Distribution
Where IL6ST is mutated · all tissues, split by cell line vs tissue
How many mutations in IL6ST were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,272 mutations in IL6ST
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|