Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 81 | 70 | 0 |
| Samples | 72 | 65 | 0 |
| Peptides | 47 | 36 | 0 |
Function
IRAG2 · Inositol 1,4,5-triphosphate receptor associated 2
The protein encode dby this gene is expressed in a developmentally regulated manner in lymphoid cell lines and tissues. The protein is localized to the cytoplasmic face of the endoplasmic reticulum. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000636465 | A0A1B0GU45* | 62 | 28 |
| ENST00000556887 | Q12912-2 | 19 | 19 |
Gene Properties
Recurrent Mutations
All 19 amino-acid changes on canonical ENST00000556887 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in IRAG2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in IRAG2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Cell Non-Hodgkins Lymphoma | 1/26 4% | 0/0 0% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Glioblastoma | 1/98 1% | 0/0 0% |
| Endometrial Carcinoma | 4/42 10% | 1/612 0% |
| Melanoma | 11/210 5% | 1/1899 0% |
| Germ Cell Tumour | 1/25 4% | 0/169 0% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
| Mesothelioma | 1/62 2% | 0/165 0% |
| Burkitts Lymphoma | 1/32 3% | 0/196 0% |
| Neuroendocrine Tumour | 3/154 2% | 0/577 0% |
| Ewings Sarcoma | 1/63 2% | 0/262 0% |
| Non-Small Cell Lung Carcinoma | 4/304 1% | 1/1390 0% |
| Other Sarcomas | 2/69 3% | 0/699 0% |
| Colorectal Carcinoma | 7/143 5% | 1/3239 0% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 0/810 0% |
| Cervical Carcinoma | 0/35 0% | 1/422 0% |
| Non-Cancerous | 2/104 2% | 0/830 0% |
| Other Solid Cancers | 3/94 3% | 0/1515 0% |
| Neuroblastoma | 2/87 2% | 0/1331 0% |
| Breast Carcinoma | 4/144 3% | 0/3264 0% |
| Gastric Carcinoma | 1/74 1% | 1/1809 0% |
| Prostate Carcinoma | 1/13 8% | 1/2105 0% |
| Ovarian Carcinoma | 1/109 1% | 0/998 0% |
| Hepatocellular Carcinoma | 2/46 4% | 0/2210 0% |
| Other Blood Cancers | 2/61 3% | 0/2725 0% |
| Pancreatic Carcinoma | 1/89 1% | 0/1611 0% |
| Head and Neck Carcinoma | 1/85 1% | 0/1574 0% |
| Kidney Carcinoma | 1/85 1% | 0/1862 0% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 0/2550 0% |
| B-Lymphoblastic Leukemia | 1/55 2% | 0/2640 0% |
Mutation Distribution
Where IRAG2 is mutated · all tissues, split by cell line vs tissue
How many mutations in IRAG2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 81 mutations in IRAG2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|