Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 581 | 99 | 477 |
| Samples | 400 | 69 | 328 |
| Peptides | 319 | 57 | 270 |
Function
IREB2 · Iron responsive element binding protein 2
The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 313 amino-acid changes on canonical ENST00000258886 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in IREB2 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in IREB2 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 7/133 5% |
| Endometrial Carcinoma | 6/42 14% | 22/612 4% |
| Melanoma | 7/210 3% | 53/1899 3% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Bladder Carcinoma | 2/58 3% | 17/956 2% |
| Other Solid Cancers | 2/94 2% | 27/1515 2% |
| Plasma Cell Myeloma | 4/44 9% | 1/305 0% |
| Non-Small Cell Lung Carcinoma | 10/304 3% | 14/1390 1% |
| Colorectal Carcinoma | 12/143 8% | 28/3239 1% |
| Cervical Carcinoma | 0/35 0% | 5/422 1% |
| Neuroendocrine Tumour | 5/154 3% | 3/577 1% |
| Germ Cell Tumour | 0/25 0% | 2/169 1% |
| Breast Carcinoma | 4/144 3% | 30/3264 1% |
| Gastric Carcinoma | 2/74 3% | 16/1809 1% |
| Hepatocellular Carcinoma | 2/46 4% | 18/2210 1% |
| Biliary Tract Carcinoma | 1/54 2% | 7/950 1% |
| Head and Neck Carcinoma | 0/85 0% | 12/1574 1% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 6/810 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 5/752 1% |
| Esophageal Carcinoma | 0/23 0% | 5/769 1% |
| Prostate Carcinoma | 1/13 8% | 11/2105 1% |
| Pancreatic Carcinoma | 0/89 0% | 8/1611 0% |
| Burkitts Lymphoma | 1/32 3% | 0/196 0% |
| Kidney Carcinoma | 0/85 0% | 7/1862 0% |
| Non-Cancerous | 0/104 0% | 3/830 0% |
| Ovarian Carcinoma | 1/109 1% | 2/998 0% |
| B-Cell Non-Hodgkins Lymphoma | 0/88 0% | 7/2534 0% |
| Other Sarcomas | 0/69 0% | 2/699 0% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 5/2550 0% |
Mutation Distribution
Where IREB2 is mutated · all tissues, split by cell line vs tissue
How many mutations in IREB2 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 581 mutations in IREB2
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|