Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,531 | 228 | 1,274 |
| Samples | 215 | 45 | 166 |
| Peptides | 208 | 40 | 169 |
Function
IRF3 · Interferon regulatory factor 3
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. The protein plays an important role in the innate immune response against DNA and RNA viruses. Mutations in this gene are associated with Encephalopathy, acute, infection-induced, herpes-specific, 7. [provided by RefSeq, Sep 2020].
Isoforms & Proteins
14 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000601291 | Q14653-4 | 188 | 135 |
| ENST00000377139 | Q14653 | 178 | 130 |
| ENST00000309877 | Q14653 | 157 | 122 |
| ENST00000597198 | Q14653 | 157 | 122 |
| ENST00000600911 | M0QZB7* | 156 | 119 |
| ENST00000599223 | Q14653-2 | 105 | 78 |
| ENST00000377135 | M0QYT9* | 104 | 79 |
| ENST00000593922 | M0QYT9* | 104 | 79 |
| ENST00000598808 | M0QYT9* | 104 | 79 |
| ENST00000599144 | M0QYT9* | 104 | 79 |
| ENST00000596765 | Q14653-3 | 52 | 35 |
| ENST00000600022 | Q14653-3 | 52 | 35 |
| ENST00000596822 | M0QX56* | 51 | 32 |
| ENST00000442265 | Q14653-5 | 19 | 17 |
Gene Properties
Recurrent Mutations
All 135 amino-acid changes on canonical ENST00000601291 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in IRF3 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in IRF3 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 6/40 15% | 0/0 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 4/133 3% |
| Hodgkins Lymphoma | 2/16 12% | 1/122 1% |
| Endometrial Carcinoma | 1/42 2% | 6/612 1% |
| Melanoma | 5/210 2% | 17/1899 1% |
| Ovarian Carcinoma | 0/109 0% | 11/998 1% |
| Colorectal Carcinoma | 10/143 7% | 23/3239 1% |
| Bladder Carcinoma | 1/58 2% | 8/956 1% |
| Non-Small Cell Lung Carcinoma | 6/304 2% | 6/1390 0% |
| Gastric Carcinoma | 0/74 0% | 11/1809 1% |
| Small Cell Lung Carcinoma | 0/9 0% | 4/752 1% |
| Osteosarcoma | 1/45 2% | 0/166 0% |
| Burkitts Lymphoma | 0/32 0% | 1/196 1% |
| Cervical Carcinoma | 0/35 0% | 2/422 0% |
| Non-Cancerous | 0/104 0% | 4/830 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 7/1592 0% |
| Glioma | 0/52 0% | 9/2127 0% |
| Biliary Tract Carcinoma | 1/54 2% | 3/950 0% |
| Breast Carcinoma | 2/144 1% | 11/3264 0% |
| Other Solid Cancers | 1/94 1% | 5/1515 0% |
| Head and Neck Carcinoma | 2/85 2% | 4/1574 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 9/2550 0% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 3/810 0% |
| Ewings Sarcoma | 1/63 2% | 0/262 0% |
| Plasma Cell Myeloma | 1/44 2% | 0/305 0% |
| Hepatocellular Carcinoma | 0/46 0% | 6/2210 0% |
| Prostate Carcinoma | 0/13 0% | 5/2105 0% |
| B-Cell Non-Hodgkins Lymphoma | 1/88 1% | 4/2534 0% |
| Kidney Carcinoma | 1/85 1% | 2/1862 0% |
| Neuroendocrine Tumour | 1/154 1% | 0/577 0% |
Mutation Distribution
Where IRF3 is mutated · all tissues, split by cell line vs tissue
How many mutations in IRF3 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,531 mutations in IRF3
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|