Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 974 | 172 | 785 |
| Samples | 873 | 148 | 709 |
| Peptides | 676 | 99 | 591 |
Function
IRS4 · Insulin receptor substrate 4
IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000372129 | A0A804CF45* | 970 | 673 |
| ENST00000564206 | O14654 | 4 | 3 |
Gene Properties
Recurrent Mutations
All 3 amino-acid changes on canonical ENST00000564206 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in IRS4 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in IRS4 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 7/40 18% | 0/0 0% |
| Endometrial Carcinoma | 2/42 5% | 40/612 7% |
| Oral Cavity Carcinoma | 3/54 6% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 23/304 8% | 54/1390 4% |
| Rhabdomyosarcoma | 1/33 3% | 8/171 5% |
| Glioblastoma | 4/98 4% | 0/0 0% |
| Colorectal Carcinoma | 22/143 15% | 114/3239 4% |
| Hodgkins Lymphoma | 3/16 19% | 2/122 2% |
| Gastric Carcinoma | 3/74 4% | 57/1809 3% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 4/133 3% |
| Squamous Cell Lung Carcinoma | 7/57 12% | 18/810 2% |
| Unknown | 0/10 0% | 1/29 3% |
| Glioma | 0/52 0% | 54/2127 3% |
| Melanoma | 10/210 5% | 42/1899 2% |
| Bladder Carcinoma | 1/58 2% | 24/956 3% |
| Cervical Carcinoma | 2/35 6% | 9/422 2% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Hepatocellular Carcinoma | 3/46 7% | 45/2210 2% |
| Small Cell Lung Carcinoma | 0/9 0% | 16/752 2% |
| Neuroendocrine Tumour | 9/154 6% | 6/577 1% |
| Other Solid Cancers | 0/94 0% | 32/1515 2% |
| Ovarian Carcinoma | 9/109 8% | 13/998 1% |
| Osteosarcoma | 3/45 7% | 1/166 1% |
| Plasma Cell Myeloma | 5/44 11% | 1/305 0% |
| Head and Neck Carcinoma | 4/85 5% | 18/1574 1% |
| Other Sarcomas | 3/69 4% | 7/699 1% |
| Biliary Tract Carcinoma | 1/54 2% | 12/950 1% |
| Breast Carcinoma | 6/144 4% | 34/3264 1% |
| Chondrosarcoma | 0/14 0% | 1/75 1% |
| Esophageal Carcinoma | 0/23 0% | 8/769 1% |
Mutation Distribution
Where IRS4 is mutated · all tissues, split by cell line vs tissue
How many mutations in IRS4 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 35 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 974 mutations in IRS4
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|