Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 539 | 108 | 421 |
| Samples | 486 | 93 | 383 |
| Peptides | 385 | 72 | 309 |
Function
ITGA5 · Integrin subunit alpha 5
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000293379 | P08648 | 539 | 385 |
Gene Properties
Recurrent Mutations
All 385 amino-acid changes on canonical ENST00000293379 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in ITGA5 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in ITGA5 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 12/40 30% | 0/0 0% |
| Melanoma | 5/210 2% | 78/1899 4% |
| Endometrial Carcinoma | 6/42 14% | 19/612 3% |
| Unknown | 0/10 0% | 1/29 3% |
| Colorectal Carcinoma | 9/143 6% | 67/3239 2% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 14/304 5% | 18/1390 1% |
| Gastric Carcinoma | 2/74 3% | 33/1809 2% |
| Oral Cavity Carcinoma | 1/54 2% | 0/0 0% |
| Ewings Sarcoma | 4/63 6% | 1/262 0% |
| Hodgkins Lymphoma | 2/16 12% | 0/122 0% |
| Burkitts Lymphoma | 3/32 9% | 0/196 0% |
| Bladder Carcinoma | 2/58 3% | 11/956 1% |
| Meningioma | 1/3 33% | 2/252 1% |
| Neuroendocrine Tumour | 3/154 2% | 4/577 1% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 6/810 1% |
| Cervical Carcinoma | 0/35 0% | 4/422 1% |
| Mesothelioma | 2/62 3% | 0/165 0% |
| Adrenocortical Carcinoma | 0/3 0% | 1/112 1% |
| Other Solid Cancers | 2/94 2% | 12/1515 1% |
| Thyroid Gland Carcinoma | 0/45 0% | 13/1592 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 19/2550 1% |
| Kidney Carcinoma | 1/85 1% | 13/1862 1% |
| Other Sarcomas | 2/69 3% | 3/699 0% |
| Non-Cancerous | 1/104 1% | 5/830 1% |
| Glioma | 0/52 0% | 14/2127 1% |
| Esophageal Carcinoma | 0/23 0% | 5/769 1% |
| Hepatocellular Carcinoma | 0/46 0% | 14/2210 1% |
| Plasma Cell Myeloma | 0/44 0% | 2/305 1% |
Mutation Distribution
Where ITGA5 is mutated · all tissues, split by cell line vs tissue
How many mutations in ITGA5 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 539 mutations in ITGA5
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|