Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 763 | 91 | 656 |
| Samples | 367 | 46 | 312 |
| Peptides | 318 | 43 | 276 |
Function
JMJD7-PLA2G4B · JMJD7-PLA2G4B readthrough
This locus represents naturally-occurring readthrough transcription between the neighboring jumonji domain containing 7 (JMJD7) and phospholipase A2, group IVB (cytosolic) (PLA2G4B) genes. Readthrough transcripts encode fusion proteins that share amino acid sequence with each individual gene product, including a partial JmjC domain and downstream C2 and phospholipase A2 domains. Alternatively spliced transcript variants have been observed. [provided by RefSeq, Oct 2013].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 312 amino-acid changes on canonical ENST00000382448 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in JMJD7-PLA2G4B · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in JMJD7-PLA2G4B – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 5/40 12% | 0/0 0% |
| Oral Cavity Carcinoma | 3/54 6% | 0/0 0% |
| Melanoma | 3/210 1% | 47/1899 2% |
| Endometrial Carcinoma | 1/42 2% | 14/612 2% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 3/133 2% |
| Colorectal Carcinoma | 6/143 4% | 57/3239 2% |
| Burkitts Lymphoma | 1/32 3% | 2/196 1% |
| Ovarian Carcinoma | 1/109 1% | 12/998 1% |
| Gastric Carcinoma | 1/74 1% | 21/1809 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Cervical Carcinoma | 0/35 0% | 5/422 1% |
| Other Sarcomas | 1/69 1% | 7/699 1% |
| Germ Cell Tumour | 1/25 4% | 1/169 1% |
| Other Solid Cancers | 0/94 0% | 16/1515 1% |
| Bladder Carcinoma | 0/58 0% | 9/956 1% |
| Non-Cancerous | 0/104 0% | 8/830 1% |
| Squamous Cell Lung Carcinoma | 3/57 5% | 4/810 0% |
| Non-Small Cell Lung Carcinoma | 6/304 2% | 7/1390 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 12/1592 1% |
| Biliary Tract Carcinoma | 0/54 0% | 7/950 1% |
| Head and Neck Carcinoma | 1/85 1% | 10/1574 1% |
| Ewings Sarcoma | 1/63 2% | 1/262 0% |
| Kidney Carcinoma | 2/85 2% | 9/1862 0% |
| Hepatocellular Carcinoma | 1/46 2% | 10/2210 0% |
| B-Cell Non-Hodgkins Lymphoma | 0/88 0% | 11/2534 0% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 11/2550 0% |
| Neuroendocrine Tumour | 2/154 1% | 1/577 0% |
| Glioma | 0/52 0% | 8/2127 0% |
| Plasma Cell Myeloma | 0/44 0% | 1/305 0% |
| Breast Carcinoma | 4/144 3% | 6/3264 0% |
Mutation Distribution
Where JMJD7-PLA2G4B is mutated · all tissues, split by cell line vs tissue
How many mutations in JMJD7-PLA2G4B were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
Mutations
All 763 mutations in JMJD7-PLA2G4B
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|