Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 2,674 | 355 | 2,291 |
| Samples | 880 | 167 | 704 |
| Peptides | 796 | 129 | 681 |
Function
KAT6A · Lysine acetyltransferase 6A
This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with an autosomal dominant form of cognitive disability. Chromosomal translocations of this gene are associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017].
Isoforms & Proteins
4 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000265713 | Q92794 | 1,003 | 740 |
| ENST00000396930 | Q92794 | 880 | 688 |
| ENST00000406337 | A0A3F2YNX6* | 430 | 340 |
| ENST00000485568 | A5PLL3* | 361 | 288 |
Gene Properties
Recurrent Mutations
All 740 amino-acid changes on canonical ENST00000265713 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in KAT6A · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in KAT6A – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 7/40 18% | 0/0 0% |
| Acute Myeloid Leukemia | 8/90 9% | 0/0 0% |
| Endometrial Carcinoma | 9/42 21% | 47/612 8% |
| Chronic Myelogenous Leukemia | 2/25 8% | 0/0 0% |
| Melanoma | 14/210 7% | 81/1899 4% |
| Colorectal Carcinoma | 33/143 23% | 99/3239 3% |
| Acute Monocytic Leukemia | 0/1 0% | 1/25 4% |
| Gastric Carcinoma | 5/74 7% | 66/1809 4% |
| Bladder Carcinoma | 3/58 5% | 29/956 3% |
| Glioblastoma | 3/98 3% | 0/0 0% |
| Hodgkins Lymphoma | 2/16 12% | 2/122 2% |
| Cervical Carcinoma | 3/35 9% | 10/422 2% |
| Neuroendocrine Tumour | 12/154 8% | 8/577 1% |
| Non-Small Cell Lung Carcinoma | 16/304 5% | 29/1390 2% |
| Squamous Cell Lung Carcinoma | 0/57 0% | 21/810 3% |
| Other Solid Cancers | 4/94 4% | 33/1515 2% |
| Chondrosarcoma | 2/14 14% | 0/75 0% |
| Hepatocellular Carcinoma | 0/46 0% | 41/2210 2% |
| Ovarian Carcinoma | 2/109 2% | 17/998 2% |
| Small Cell Lung Carcinoma | 0/9 0% | 13/752 2% |
| Esophageal Carcinoma | 2/23 9% | 11/769 1% |
| Germ Cell Tumour | 0/25 0% | 3/169 2% |
| Ewings Sarcoma | 4/63 6% | 1/262 0% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 2/133 2% |
| Head and Neck Carcinoma | 3/85 4% | 20/1574 1% |
| Burkitts Lymphoma | 2/32 6% | 1/196 1% |
| Other Sarcomas | 0/69 0% | 10/699 1% |
| Kidney Carcinoma | 3/85 4% | 19/1862 1% |
| Breast Carcinoma | 4/144 3% | 34/3264 1% |
| Esophageal Squamous Cell Carcinoma | 0/51 0% | 27/2550 1% |
Mutation Distribution
Where KAT6A is mutated · all tissues, split by cell line vs tissue
How many mutations in KAT6A were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 2,674 mutations in KAT6A
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|