Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 741 | 124 | 611 |
| Samples | 680 | 110 | 565 |
| Peptides | 481 | 73 | 428 |
Function
KCNA4 · Potassium voltage-gated channel subfamily A member 4
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influence the duration of cardiac action potential.[provided by RefSeq, Mar 2011].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000328224 | P22459 | 741 | 481 |
Gene Properties
Recurrent Mutations
All 481 amino-acid changes on canonical ENST00000328224 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in KCNA4 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in KCNA4 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Chordoma | 1/7 14% | 0/13 0% |
| T-Lymphoblastic Leukemia | 2/40 5% | 0/0 0% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 39/810 5% |
| Non-Small Cell Lung Carcinoma | 24/304 8% | 52/1390 4% |
| Endometrial Carcinoma | 5/42 12% | 24/612 4% |
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Acute Myeloid Leukemia | 3/90 3% | 0/0 0% |
| Colorectal Carcinoma | 10/143 7% | 95/3239 3% |
| Melanoma | 6/210 3% | 51/1899 3% |
| Cervical Carcinoma | 3/35 9% | 7/422 2% |
| Gastric Carcinoma | 3/74 4% | 38/1809 2% |
| Other Solid Cancers | 0/94 0% | 33/1515 2% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 14/752 2% |
| Neuroendocrine Tumour | 6/154 4% | 6/577 1% |
| Head and Neck Carcinoma | 6/85 7% | 20/1574 1% |
| Germ Cell Tumour | 2/25 8% | 1/169 1% |
| Hodgkins Lymphoma | 2/16 12% | 0/122 0% |
| Esophageal Carcinoma | 1/23 4% | 10/769 1% |
| Hepatocellular Carcinoma | 0/46 0% | 26/2210 1% |
| Plasma Cell Myeloma | 2/44 5% | 2/305 1% |
| Other Sarcomas | 0/69 0% | 8/699 1% |
| Glioma | 2/52 4% | 20/2127 1% |
| Osteosarcoma | 2/45 4% | 0/166 0% |
| Biliary Tract Carcinoma | 1/54 2% | 8/950 1% |
| Bladder Carcinoma | 1/58 2% | 8/956 1% |
| Burkitts Lymphoma | 2/32 6% | 0/196 0% |
| Esophageal Squamous Cell Carcinoma | 2/51 4% | 19/2550 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Pancreatic Carcinoma | 1/89 1% | 11/1611 1% |
Mutation Distribution
Where KCNA4 is mutated · all tissues, split by cell line vs tissue
How many mutations in KCNA4 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 46 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 741 mutations in KCNA4
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|