Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 565 | 90 | 444 |
| Samples | 290 | 66 | 214 |
| Peptides | 204 | 50 | 153 |
Function
KCNS1 · Potassium voltage-gated channel modifier subfamily S member 1
Voltage-gated potassium channels form the largest and most diversified class of ion channels and are present in both excitable and nonexcitable cells. Their main functions are associated with the regulation of the resting membrane potential and the control of the shape and frequency of action potentials. The alpha subunits are of 2 types: those that are functional by themselves and those that are electrically silent but capable of modulating the activity of specific functional alpha subunits. The protein encoded by this gene is not functional by itself but can form heteromultimers with member 1 and with member 2 (and possibly other members) of the Shab-related subfamily of potassium voltage-gated channel proteins. This gene belongs to the S subfamily of the potassium channel family. [provided by RefSeq, Jul 2008].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 204 amino-acid changes on canonical ENST00000537075 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in KCNS1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in KCNS1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Gastrointestinal Stromal Tumour | 0/0 0% | 5/133 4% |
| T-Lymphoblastic Leukemia | 1/40 2% | 0/0 0% |
| Endometrial Carcinoma | 9/42 21% | 7/612 1% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Colorectal Carcinoma | 13/143 9% | 44/3239 1% |
| Gastric Carcinoma | 3/74 4% | 22/1809 1% |
| Mesothelioma | 3/62 5% | 0/165 0% |
| Cervical Carcinoma | 2/35 6% | 3/422 1% |
| Esophageal Squamous Cell Carcinoma | 1/51 2% | 25/2550 1% |
| Osteosarcoma | 1/45 2% | 1/166 1% |
| Esophageal Carcinoma | 0/23 0% | 7/769 1% |
| Plasma Cell Myeloma | 3/44 7% | 0/305 0% |
| Biliary Tract Carcinoma | 0/54 0% | 8/950 1% |
| Bladder Carcinoma | 0/58 0% | 8/956 1% |
| Other Sarcomas | 2/69 3% | 4/699 1% |
| Non-Cancerous | 1/104 1% | 6/830 1% |
| Melanoma | 5/210 2% | 10/1899 1% |
| Non-Small Cell Lung Carcinoma | 5/304 2% | 7/1390 0% |
| Other Solid Cancers | 4/94 4% | 4/1515 0% |
| Thyroid Gland Carcinoma | 0/45 0% | 8/1592 0% |
| Glioma | 0/52 0% | 10/2127 0% |
| Hepatocellular Carcinoma | 2/46 4% | 7/2210 0% |
| Ovarian Carcinoma | 0/109 0% | 4/998 0% |
| Squamous Cell Lung Carcinoma | 1/57 2% | 2/810 0% |
| B-Cell Non-Hodgkins Lymphoma | 3/88 3% | 5/2534 0% |
| Neuroendocrine Tumour | 0/154 0% | 2/577 0% |
| Pancreatic Carcinoma | 0/89 0% | 4/1611 0% |
| Breast Carcinoma | 2/144 1% | 6/3264 0% |
| Other Blood Cancers | 0/61 0% | 6/2725 0% |
| Medulloblastoma | 0/0 0% | 1/450 0% |
Mutation Distribution
Where KCNS1 is mutated · all tissues, split by cell line vs tissue
How many mutations in KCNS1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 565 mutations in KCNS1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|