Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,337 | 224 | 1,093 |
| Samples | 1,153 | 191 | 946 |
| Peptides | 862 | 132 | 749 |
Function
KDR · Kinase insert domain receptor
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009].
Isoforms & Proteins
1 transcript · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
| Transcript | UniProt | Mutations | Peptides |
|---|---|---|---|
| ENST00000263923 | P35968 | 1,337 | 862 |
Gene Properties
Recurrent Mutations
All 862 amino-acid changes on canonical ENST00000263923 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in KDR · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in KDR – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Cell Non-Hodgkins Lymphoma | 3/26 12% | 0/0 0% |
| Melanoma | 21/210 10% | 163/1899 9% |
| T-Lymphoblastic Leukemia | 3/40 8% | 0/0 0% |
| Endometrial Carcinoma | 7/42 17% | 33/612 5% |
| Non-Small Cell Lung Carcinoma | 25/304 8% | 76/1390 5% |
| Other Solid Cancers | 4/94 4% | 81/1515 5% |
| Squamous Cell Lung Carcinoma | 2/57 4% | 42/810 5% |
| Colorectal Carcinoma | 29/143 20% | 125/3239 4% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 6/133 5% |
| Rhabdomyosarcoma | 0/33 0% | 9/171 5% |
| Neuroendocrine Tumour | 17/154 11% | 13/577 2% |
| Chronic Myelogenous Leukemia | 1/25 4% | 0/0 0% |
| Small Cell Lung Carcinoma | 0/9 0% | 29/752 4% |
| Osteosarcoma | 3/45 7% | 4/166 2% |
| Other Sarcomas | 5/69 7% | 19/699 3% |
| Hodgkins Lymphoma | 3/16 19% | 1/122 1% |
| Bladder Carcinoma | 5/58 9% | 21/956 2% |
| Unknown | 0/10 0% | 1/29 3% |
| Gastric Carcinoma | 1/74 1% | 45/1809 2% |
| Acute Myeloid Leukemia | 2/90 2% | 0/0 0% |
| Hepatocellular Carcinoma | 2/46 4% | 47/2210 2% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Mesothelioma | 3/62 5% | 1/165 1% |
| Germ Cell Tumour | 1/25 4% | 2/169 1% |
| Ovarian Carcinoma | 5/109 5% | 12/998 1% |
| Cervical Carcinoma | 2/35 6% | 5/422 1% |
| Esophageal Carcinoma | 0/23 0% | 12/769 2% |
| Glioma | 4/52 8% | 29/2127 1% |
| Non-Cancerous | 1/104 1% | 13/830 2% |
| Biliary Tract Carcinoma | 0/54 0% | 13/950 1% |
Mutation Distribution
Where KDR is mutated · all tissues, split by cell line vs tissue
How many mutations in KDR were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,337 mutations in KDR
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|