Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,652 | 268 | 1,364 |
| Samples | 814 | 166 | 644 |
| Peptides | 500 | 101 | 436 |
Function
KEAP1 · Kelch like ECH associated protein 1
This gene encodes a cytoplasmic regulatory protein that plays a role in the cellular response to oxidative and electrophilic stress. The encoded protein regulates NRF2, a transcription factor that controls the expression of antioxidant and cytoprotective genes. Under non-stress conditions, KEAP1 binds NRF2 and promotes its ubiquitination and proteasomal degradation, thereby maintaining low NRF2 levels. During oxidative or electrophilic stress, conformational changes in KEAP1 impair its ability to promote NRF2 degradation, allowing NRF2 to activate genes that protect cells from oxidative damage and toxic insults. [provided by RefSeq, Mar 2026].
Isoforms & Proteins
3 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 500 amino-acid changes on canonical ENST00000171111 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in KEAP1 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in KEAP1 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| Oral Cavity Carcinoma | 8/54 15% | 0/0 0% |
| Non-Small Cell Lung Carcinoma | 63/304 21% | 151/1390 11% |
| Chronic Myelogenous Leukemia | 3/25 12% | 0/0 0% |
| T-Lymphoblastic Leukemia | 4/40 10% | 0/0 0% |
| Squamous Cell Lung Carcinoma | 6/57 11% | 72/810 9% |
| Small Cell Lung Carcinoma | 0/9 0% | 37/752 5% |
| Endometrial Carcinoma | 10/42 24% | 17/612 3% |
| Neuroendocrine Tumour | 13/154 8% | 12/577 2% |
| Hepatocellular Carcinoma | 3/46 7% | 65/2210 3% |
| Esophageal Squamous Cell Carcinoma | 3/51 6% | 55/2550 2% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Bladder Carcinoma | 4/58 7% | 14/956 1% |
| Mesothelioma | 3/62 5% | 1/165 1% |
| Head and Neck Carcinoma | 0/85 0% | 29/1574 2% |
| Cervical Carcinoma | 2/35 6% | 4/422 1% |
| Esophageal Carcinoma | 0/23 0% | 10/769 1% |
| Ovarian Carcinoma | 8/109 7% | 6/998 1% |
| Biliary Tract Carcinoma | 7/54 13% | 5/950 1% |
| Gastric Carcinoma | 1/74 1% | 21/1809 1% |
| Other Sarcomas | 0/69 0% | 9/699 1% |
| Colorectal Carcinoma | 10/143 7% | 27/3239 1% |
| Germ Cell Tumour | 0/25 0% | 2/169 1% |
| Rhabdomyosarcoma | 0/33 0% | 2/171 1% |
| Melanoma | 2/210 1% | 17/1899 1% |
| Other Solid Cancers | 1/94 1% | 12/1515 1% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 1/133 1% |
| Hodgkins Lymphoma | 0/16 0% | 1/122 1% |
| Kidney Carcinoma | 1/85 1% | 13/1862 1% |
| Prostate Carcinoma | 4/13 31% | 10/2105 0% |
| Breast Carcinoma | 0/144 0% | 18/3264 1% |
Mutation Distribution
Where KEAP1 is mutated · all tissues, split by cell line vs tissue
How many mutations in KEAP1 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,652 mutations in KEAP1
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|