Stats by Source
Total, split by cell line (COSMIC CL / DepMap / PubMed) vs tissue (COSMIC primary tissue)
Total = all mutations for this gene across every source.
Cell line = COSMIC Cell Lines Project + DepMap + PubMed.
Tissue = COSMIC primary-tissue (patient tumour) samples.
Total can exceed cell line + tissue: COSMIC tissue-derived models sit only in global, and a peptide can be shared across both.
| Total | Cell line | Tissue | |
|---|---|---|---|
| Mutations | 1,499 | 260 | 1,222 |
| Samples | 686 | 152 | 527 |
| Peptides | 566 | 101 | 467 |
Function
KIF14 · Kinesin family member 14
This gene encodes a member of the kinesin-3 superfamily of microtubule motor proteins. These proteins are involved in numerous processes including vesicle transport, chromosome segregation, mitotic spindle formation, and cytokinesis. In human HeLa-S3 and 293T cells, this protein is localized to the cytoplasm during interphase, to the spindle poles and spindle microtubules during mitosis, and to the midbody during cytokinesis. An internal motor domain displays microtubule-dependent ATPase activity, consistent with its function as a microtubule motor protein. Knockdown of this gene results in failed cytokinesis with endoreplication, which results in multinucleated cells. This gene has been identified as a likely oncogene in breast, lung and ovarian cancers, as well as retinoblastomas and gliomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015].
Isoforms & Proteins
2 transcripts · UniProt mapping is sequence-verified (AA-safe)
Each Ensembl transcript (ENST) this gene is mutated on, with its matched UniProt accession.
The mapping is sequence-verified: the UniProt sequence is identical to the transcript translation, so amino-acid positions line up exactly. A * marks an unreviewed (TrEMBL) entry.
Counts are mutations and unique mutant peptides on each transcript.
Gene Properties
Recurrent Mutations
All 566 amino-acid changes on canonical ENST00000367350 · needle height = samples · drag the mini-map to zoom
A lollipop / needle plot – the standard way to show recurrent mutations along a protein (as used by cBioPortal and MutationMapper).
X-axis = amino-acid position in the protein.
Needle height & head size = how often that exact amino-acid change was observed (its recurrence). Tall/large heads are mutational hotspots.
The most recurrent changes are labelled; hover any needle for the change, position and counts.
Mutation frequency across cancer types
% of samples with a missense/complex mutation in KIF14 · cell line vs tissue
For each cancer type, the fraction of samples that carry at least one missense/complex mutation anywhere in KIF14 – counted as distinct samples (a sample counts once no matter how many mutations it has).
Split into cell line and tissue; each cell shows mutated / total and the percentage. Cohorts with <20 samples are omitted. Ordered by combined frequency.
| Cancer type | Cell lines | Tissue samples |
|---|---|---|
| T-Lymphoblastic Leukemia | 5/40 12% | 0/0 0% |
| Endometrial Carcinoma | 13/42 31% | 43/612 7% |
| Thymic Epithelial Tumor | 0/0 0% | 2/39 5% |
| Gastrointestinal Stromal Tumour | 0/0 0% | 6/133 5% |
| Melanoma | 9/210 4% | 86/1899 5% |
| Chronic Myelogenous Leukemia | 1/25 4% | 0/0 0% |
| Oral Cavity Carcinoma | 2/54 4% | 0/0 0% |
| Squamous Cell Lung Carcinoma | 9/57 16% | 18/810 2% |
| Non-Small Cell Lung Carcinoma | 20/304 7% | 28/1390 2% |
| Gastric Carcinoma | 4/74 5% | 37/1809 2% |
| Hodgkins Lymphoma | 2/16 12% | 1/122 1% |
| Colorectal Carcinoma | 13/143 9% | 57/3239 2% |
| Neuroendocrine Tumour | 11/154 7% | 4/577 1% |
| Glioblastoma | 2/98 2% | 0/0 0% |
| Cervical Carcinoma | 4/35 11% | 5/422 1% |
| Bladder Carcinoma | 0/58 0% | 20/956 2% |
| Other Solid Cancers | 2/94 2% | 28/1515 2% |
| Burkitts Lymphoma | 3/32 9% | 1/196 1% |
| Small Cell Lung Carcinoma | 1/9 11% | 12/752 2% |
| Osteosarcoma | 3/45 7% | 0/166 0% |
| Non-Cancerous | 3/104 3% | 10/830 1% |
| Mesothelioma | 3/62 5% | 0/165 0% |
| Plasma Cell Myeloma | 2/44 5% | 2/305 1% |
| Acute Myeloid Leukemia | 1/90 1% | 0/0 0% |
| Ovarian Carcinoma | 7/109 6% | 5/998 0% |
| Germ Cell Tumour | 0/25 0% | 2/169 1% |
| Esophageal Carcinoma | 0/23 0% | 8/769 1% |
| Hepatocellular Carcinoma | 1/46 2% | 21/2210 1% |
| Esophageal Squamous Cell Carcinoma | 2/51 4% | 22/2550 1% |
| Other Sarcomas | 0/69 0% | 7/699 1% |
Mutation Distribution
Where KIF14 is mutated · all tissues, split by cell line vs tissue
How many mutations in KIF14 were found in each tissue, across the whole database.
Each bar is a tissue (cell-line and tissue names are merged to the standard tissue), split into cell line and tissue (patient tumour) contributions.
This shows the cancer-context where this gene is recurrently altered.
GTEx Expression
Median TPM across 54 healthy tissues
Median gene expression (TPM) in normal, non-cancer human tissues from the GTEx project.
Useful for judging tumour specificity – a strong neoantigen target ideally comes from a gene with low expression in healthy tissues.
Scroll or drag the mini-axis below the chart to browse all tissues.
Mutations
All 1,499 mutations in KIF14
Every mutation record for this gene, across all samples and sources.
The Sample column links to the cell line (cell-line samples) or the tissue type (tissue samples).
Use the Type / Source filters, the search box, and column sorting to explore; each CAN-IMMUNE ID opens the full mutation & peptide view.
| ID | Sample | Transcript | AA Change | CDS | Type | Source | Mutant Peptide | Wild-type Peptide |
|---|